Last Updated: May 10, 2026

Claims for Patent: 9,765,379

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Summary for Patent: 9,765,379

Title:	Harvest operations for recombinant proteins
Abstract:	The present invention contemplates methods of producing a recombinant protein comprising fermenting a prokaryotic host cell wherein said prokaryotic host cell has been transformed with a nucleic acid encoding said recombinant protein, harvesting said recombinant protein under conditions where dOlevels are greater than 0%, purifying said recombinant protein to a filtered bulk, wherein said filtered bulk does not contain detectable DHNA-recombinant protein adduct, as measured by an IEC assay at 310 nm. Furthermore, method of producing a recombinant protein comprising fermenting a menE gene-deleted prokaryotic host cell wherein said prokaryotic host cell has been transformed with a nucleic acid encoding said recombinant protein, harvesting said recombinant protein, purifying said recombinant protein to a filtered bulk, wherein said filtered bulk does not contain detectable DHNA-recombinant protein adduct, as measured by an IEC assay at 310 nm, wherein the recombinant protein yield is increased by about 20% or greater is contemplated.
Inventor(s):	Laird Michael W., St. John Richard, Gunson Jane V., Kaleas Kimberly, Nadarajah Deepa, Adams Rachel L E, Snedecor Bradley R.
Assignee:	Genentech, Inc.
Application Number:	US14497964

Details for Patent 9,765,379

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Genentech, Inc.	LUCENTIS	ranibizumab	Injection	125156	June 30, 2006	⤷ Start Trial	2034-09-26
Genentech, Inc.	LUCENTIS	ranibizumab	Injection	125156	August 10, 2012	⤷ Start Trial	2034-09-26
Genentech, Inc.	LUCENTIS	ranibizumab	Injection	125156	October 13, 2016	⤷ Start Trial	2034-09-26
Genentech, Inc.	LUCENTIS	ranibizumab	Injection	125156	March 20, 2018	⤷ Start Trial	2034-09-26
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 9,765,379

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Country	Patent Number	Estimated Expiration
South Africa	201406434	⤷ Start Trial
World Intellectual Property Organization (WIPO)	2013148249	⤷ Start Trial
United States of America	2025137027	⤷ Start Trial
United States of America	2024158825	⤷ Start Trial
>Country	>Patent Number	>Estimated Expiration

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