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Last Updated: April 18, 2024

Claims for Patent: 9,732,149

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Summary for Patent: 9,732,149

Title:	Treatment of paroxysmal nocturnal hemoglobinuria patients by an inhibitor of complement
Abstract:	Eculizumab, a humanized monoclonal antibody against C5 that inhibits terminal complement activation, showed activity in a preliminary 12-week open-label trial in a small cohort of patients with paroxysmal nocturnal hemoglobinuria (PNH). The present study examined whether chronic eculizumab therapy could reduce intravascular hemolysis, stabilize hemoglobin levels, reduce transfusion requirements, and improve quality of life in a double-blind, randomized, placebo-controlled, multi-center global Phase III trial. It has been found that eculizumab stabilized hemoglobin levels, decreased the need for transfusions, and improved quality of life in PNH patients via reduced intravascular hemolysis. Chronic eculizumab treatment appears to be a safe and effective therapy for PNH.
Inventor(s):	Bell; Leonard (Woodbridge, CT), Rother; Russell P. (Oklahoma City, OK), Evans; Mark J. (Radnor, PA)
Assignee:	Alexion Pharmaceuticals, Inc. (New Haven, CT)
Application Number:	15/284,015
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 9,732,149
Patent Claims:	1. An antibody that binds C5 comprising a heavy chain consisting of SEQ ID NO: 2 and a light chain consisting of SEQ ID NO: 4.

Details for Patent 9,732,149

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Alexion Pharmaceuticals, Inc.	SOLIRIS	eculizumab	Injection	125166	03/16/2007	⤷ Try a Trial	2027-03-15
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 9,732,149

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Country	Patent Number	Estimated Expiration
Australia	2005209854	⤷ Try a Trial
Australia	2007225044	⤷ Try a Trial
Australia	2007328435	⤷ Try a Trial
Brazil	122017024057	⤷ Try a Trial
Brazil	PI0708909	⤷ Try a Trial
>Country	>Patent Number	>Estimated Expiration

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