Claims for Patent: 9,566,329

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Summary for Patent: 9,566,329

Title:	Live, attenuated rubella vector to express vaccine antigens
Abstract:	Disclosed herein are isolated rubella viral vector constructs that include a rubella non-structural protein open reading frame (ORF) without an in-frame deletion, a rubella structural protein ORF, and a heterologous antigenic insert. In one example, the heterologous antigenic insert is positioned within the rubella structural protein ORF. In some examples, the heterologous antigenic insert is positioned in the rubella structural protein ORF in between a gene encoding structural protein E2 and a gene encoding structural protein E1. Exemplary antigenic inserts include HIV, SIV, RSV or hepatitis B surface antigens. In some examples, the HIV antigenic insert is a Gag antigenic insert, a gp41 antigenic insert or a gp120 antigenic insert. Also disclosed are uses of the isolated rubella viral vector, such as to induce an immune response to a particular virus, such as HIV-1, testing sensitivity to neutralizing antibodies, or screening antiviral drugs (such as protease inhibitors).
Inventor(s):	Ira Berkower, Konstantin Virnik
Assignee:	US Department of Health and Human Services
Application Number:	US14/387,514

Details for Patent 9,566,329

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Btg International Inc.	VORAXAZE	glucarpidase	For Injection	125327	January 17, 2012	9,566,329	2033-04-08
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 9,566,329

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Country	Patent Number	Estimated Expiration
United States of America	2015079123	⤷ Start Trial
World Intellectual Property Organization (WIPO)	2013152352	⤷ Start Trial
>Country	>Patent Number	>Estimated Expiration

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