Claims for Patent: 9,566,327

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Summary for Patent: 9,566,327

Title:	Computationally optimized broadly reactive antigens for human and avian H5N1 influenza
Abstract:	Described herein is the generation of optimized H5N1 influenza HA polypeptides for eliciting a broadly reactive immune response to H5N1 influenza virus isolates. The optimized HA polypeptides were developed through a series of HA protein alignments, and subsequent generation of consensus sequences, based on human and avian H5N1 isolates. Provided herein are optimized H5N1 HA polypeptides, and compositions, fusion proteins and VLPs comprising the HA polypeptides. Further provided are codon-optimized nucleic acid sequences encoding the HA polypeptides. Methods of eliciting an immune response against influenza virus in a subject are also provided by the present disclosure.
Inventor(s):	Ted M. Ross, Corey J. Crevar, Brendan M. Giles
Assignee:	University of Pittsburgh
Application Number:	US14/377,633

Details for Patent 9,566,327

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Emergent Biosolutions Canada Inc.	ACCRETROPIN	somatropin	Injection	021538	January 23, 2008	9,566,327	2033-02-08
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 9,566,327

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Country	Patent Number	Estimated Expiration
World Intellectual Property Organization (WIPO)	2013122827	⤷ Get Started Free
United States of America	2019092820	⤷ Get Started Free
United States of America	2017107262	⤷ Get Started Free
>Country	>Patent Number	>Estimated Expiration

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