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Last Updated: December 28, 2025

Claims for Patent: 9,452,203

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Summary for Patent: 9,452,203

Title:	Use of C1-inhibitor for the treatment of secondary edema of the central nervous system
Abstract:	The subject of the present invention is, in the most general aspect, the prevention and/or treatment of a secondary edema. In particular, the present invention relates to a C1-Inhibitor for use in a method of preventing the formation and/or reducing the size of a secondary edema of the central nervous system (CNS) in a subject wherein the subject has or has had at least one disorder selected from the group consisting of stroke, ischemic stroke, hemorrhagic stroke, perinatal stroke, traumatic brain injury and spinal cord injury. Preferably the secondary edema of the CNS is a secondary brain edema. Another subject of the present invention is the treatment of disorders associated with an increased permeability of the blood brain barrier or the blood spinal cord barrier. And a third subject is a plasma-derived C1-inhibitor for use in a method of preventing, reducing or treating brain ischemia-reperfusion injury.
Inventor(s):	Kleinschnitz Christoph, Nolte Marc, Stoll Guido, Dickneite Gerhard, Schulte Stefan, Nieswandt Bernhard, Pragst Ingo
Assignee:	CSL BEHRING GMBH
Application Number:	US14364097
Patent Claims:

Details for Patent 9,452,203

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Takeda Pharmaceuticals U.s.a., Inc.	CINRYZE	c1 esterase inhibitor (human)	For Injection	125267	October 10, 2008	⤷ Get Started Free	2032-12-21
Csl Behring Gmbh	BERINERT	c1 esterase inhibitor (human)	For Injection	125287	October 09, 2009	⤷ Get Started Free	2032-12-21
Pharming Americas Bv	RUCONEST	c1 esterase inhibitor (recombinant)	For Injection	125495	July 16, 2014	⤷ Get Started Free	2032-12-21
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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