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Last Updated: January 26, 2022

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Claims for Patent: 9,181,632

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Summary for Patent: 9,181,632
Title:C.difficile toxin B CROP domain peptides, antibodies and complexes thereof
Abstract: The present invention provides polypeptide domains of C. difficile toxin B (B1, B2, B3, B4) and complexes between the polypeptides and antibodies that bind specifically for the polypeptide. Methods of using the polypeptides to generate antibodies are also provided.
Inventor(s): Murgolo; Nicholas (Millington, NJ), Hernandez; Lorraine (Warren, NJ), Sheth; Payal (Somerset, NJ), Strickland; Corey (Martinsville, NJ), Orth; Peter (Bronxville, NY), Therien; Alex (Fanwood, NJ), Reichert; Paul (Montville, NJ), Xiao; Li (Cranbury, NJ)
Assignee: MERCK SHARP & DOHME CORP. (Rahway, NJ)
Application Number:14/479,735
Patent Claims:1. An isolated crystal comprising a bezlotoxumab Fab fragment complexed to a polypeptide comprising SEQ ID NO: 14, wherein said polypeptide is C. difficile toxin B amino acids 1834-2101 and wherein the crystal is characterized by: space group: P21; and unit cell dimensions: a=79.413 .ANG., b=134.659 .ANG., c=102.579 .ANG., .alpha.=.gamma.=90.degree., .beta.=112.559.degree..

2. The crystal of claim 1, wherein said polypeptide is characterized by structure coordinates comprising a root mean square deviation (RMSD) of conserved residue backbone atoms of less than about 2.0 angstroms when superimposed on backbone atoms described by structural coordinates of Table 1.

3. A method for producing a crystalline complex of claim 1 comprising incubating a first solution comprising 10 mg/ml of the complex, 5 mM phosphate, pH 7.4, 68.5 mM sodium chloride, 1.35 mM potassium chloride and 2.2% polyethylene glycol 4000 in a sealed container in close proximity to a second solution comprising 4.4 polyethylene glycol 4000.

4. The method of claim 3 wherein the first solution is in the form of a drop which is hanging or sitting on a surface.

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Serving leading biopharmaceutical companies globally:

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