Unlock all Features See Plans and Pricing

Serving leading biopharmaceutical companies globally:

Boehringer Ingelheim
McKesson
Express Scripts
Colorcon
Moodys
Harvard Business School

Last Updated: January 26, 2022

DrugPatentWatch Database Preview

Claims for Patent: 9,181,632

➤ Subscribe for complete access

« Back to Dashboard

Summary for Patent: 9,181,632
Title:C.difficile toxin B CROP domain peptides, antibodies and complexes thereof
Abstract: The present invention provides polypeptide domains of C. difficile toxin B (B1, B2, B3, B4) and complexes between the polypeptides and antibodies that bind specifically for the polypeptide. Methods of using the polypeptides to generate antibodies are also provided.
Inventor(s): Murgolo; Nicholas (Millington, NJ), Hernandez; Lorraine (Warren, NJ), Sheth; Payal (Somerset, NJ), Strickland; Corey (Martinsville, NJ), Orth; Peter (Bronxville, NY), Therien; Alex (Fanwood, NJ), Reichert; Paul (Montville, NJ), Xiao; Li (Cranbury, NJ)
Assignee: MERCK SHARP & DOHME CORP. (Rahway, NJ)
Application Number:14/479,735
Patent Claims:1. An isolated crystal comprising a bezlotoxumab Fab fragment complexed to a polypeptide comprising SEQ ID NO: 14, wherein said polypeptide is C. difficile toxin B amino acids 1834-2101 and wherein the crystal is characterized by: space group: P21; and unit cell dimensions: a=79.413 .ANG., b=134.659 .ANG., c=102.579 .ANG., .alpha.=.gamma.=90.degree., .beta.=112.559.degree..

2. The crystal of claim 1, wherein said polypeptide is characterized by structure coordinates comprising a root mean square deviation (RMSD) of conserved residue backbone atoms of less than about 2.0 angstroms when superimposed on backbone atoms described by structural coordinates of Table 1.

3. A method for producing a crystalline complex of claim 1 comprising incubating a first solution comprising 10 mg/ml of the complex, 5 mM phosphate, pH 7.4, 68.5 mM sodium chloride, 1.35 mM potassium chloride and 2.2% polyethylene glycol 4000 in a sealed container in close proximity to a second solution comprising 4.4 polyethylene glycol 4000.

4. The method of claim 3 wherein the first solution is in the form of a drop which is hanging or sitting on a surface.

Make Better Decisions: Try a trial or see plans & pricing

Serving leading biopharmaceutical companies globally:

Express Scripts
Medtronic
Harvard Business School
Baxter
McKinsey
Moodys

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.