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Last Updated: April 24, 2024

Claims for Patent: 8,920,792

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Summary for Patent: 8,920,792

Title:	Injection of collagenase in the treatment of herniated meniscus
Abstract:	A method of treating a human patient having a herniated meniscus is disclosed that includes first identifying the precise location of the herniated meniscus fragment and then injecting a therapeutically effective amount of collagenase clostridium histolyticum directly into the tissue using a hypodermic needle and syringe to dissolve the fragment.
Inventor(s):	Sussman; Bernard (Washington, DC)
Assignee:
Application Number:	14/067,588
Patent Claims:	1. A method of treating a human patient having a herniated meniscus of the knee, comprising, identifying the location of said herniated portion of the meniscus and then injecting a therapeutically effective amount of collagenase clostridium histolyticum directly into said herniated meniscus tissue using a hypodermic needle and syringe to substantially break down said herniated portion. 2. The method of treatment recited in claim 1 wherein said therapeutically effective amount substantially completely dissolves said herniated meniscus tissue. 3. The method of treatment recited in claim 1 wherein said therapeutically effective amount is between 0.5 and 1.5 cc. of 0.1 percent solution of purified collagenase clostridium histolyticum in sterile aqueous solution. 4. The method of treatment recited in claim 3 wherein said sterile aqueous solution further comprises calcium phosphate. 5. The method of treatment recited in claim 1 wherein said therapeutically effective amount is between 0.5 and 5.0 cc. of 0.1 percent solution of purified collagenase clostridium histolyticum in sterile aqueous solution. 6. The method recited in claim 1 further comprising using imaging technology to guide said needle to said herniated portion during said injection step. 7. The method recited in claim 6 wherein said imaging technology comprises ultrasound. 8. The method recited in claim 1 wherein the location of the herniated meniscus is identified using an MRI imaging system.

Details for Patent 8,920,792

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965	⤷ Try a Trial	2039-03-29
Auxilium Pharmaceuticals, Inc.	XIAFLEX	collagenase clostridium histolyticum	For Injection	125338	02/02/2010	⤷ Try a Trial	2039-03-29
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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