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Last Updated: December 6, 2021

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Claims for Patent: 8,883,862

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Summary for Patent: 8,883,862
Title:Method for controlled release of parathyroid hormone from cross-linked hyaluronic acid hydrogel
Abstract: A method for locally controlled release of an effective amount of PTH(1-34) by a hyaluronic acid based hydrogel that can injected intra-articularly for the treatment of osteoarthritis is provided.
Inventor(s): Ho; Mei-Ling (Kaohsiung, TW), Eswaramoorthy; Rajalakshmanan (Kaohsiung, TW), Wu; Shun-Cheng (Kaohsiung, TW), Wang; Gwo-Jaw (Taipei, TW), Chang; Je-Ken (Kaohsiung, TW), Fu; Yin-Chih (Kaohsiung, TW), Tzeng; Cherng-Chyi (Kaohsiung, TW), Chen; Hui-Ting (Kaohsiung, TW), Wang; Yao-Hsien (Kaohsiung, TW)
Assignee: Kaohsiung Medical University (Kaohsiung, TW)
Application Number:13/349,533
Patent Claims:1. A method for controlled release of parathyroid hormone (1-34) (PTH (1-34)) in a subject suffering from osteoarthritis, comprising: (a) providing a hydrogel consisting of a UV-irradiated cross-linked methacrylated-hyaluronic acid (CLMH) and PTH (1-34) in acid solution; and (b) administering the hydrogel to a joint of a subject suffering from osteoarthritis, wherein the hydrogel controls sustained-release of an effective amount of PTH (1-34).

2. The method of claim 1, wherein the osteoarthritis is caused by terminal differentiation of chondrocytes.

3. The method of claim 1, wherein the joint is a knee joint, hip joint, spine joint or finger joint.

4. The method of claim 1, wherein the UV-irradiated cross-linked methacrylated-hyaluronic acid encapsulates the PTH (1-34).

5. The method of claim 1, wherein the hydrogel has a three dimensional structure.

6. The method of claim 1, wherein the effective amount is from about 2.times.10.sup.-9 M to about 5.times.10.sup.-8 M.

7. The method of claim 1, wherein the effective amount is from about 4.3.times.10.sup.-9M to about 1.23.times.10.sup.-8 M.

8. The method of claim 1, wherein the administration is intra-articular injection.

9. The method of claim 1, wherein the subject is a mammal.

10. The method of claim 9, wherein the mammal is a human.

11. The method of claim 1, wherein the effective amount is from about 1.times.10.sup.-9 M to about 5.times.10.sup.-7 M.

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