Claims for Patent: 8,790,641

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Summary for Patent: 8,790,641

Title:	Production of high mannose proteins in plant culture and therapeutic uses thereof
Abstract:	A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.
Inventor(s):	Yoseph Shaaltiel, Gideon Baum, Daniel Bartfeld, Sharon Hashmueli, Ayala Lewkowicz
Assignee:	Protalix Ltd
Application Number:	US12/385,894

Details for Patent 8,790,641

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Pfizer Inc.	ELELYSO	taliglucerase alfa	For Injection	022458	May 01, 2012	⤷ Get Started Free	2029-04-23
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 8,790,641

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Country	Patent Number	Estimated Expiration
South Africa	200908423	⤷ Get Started Free
South Africa	200508680	⤷ Get Started Free
World Intellectual Property Organization (WIPO)	9813469	⤷ Get Started Free
World Intellectual Property Organization (WIPO)	2008132743	⤷ Get Started Free
World Intellectual Property Organization (WIPO)	2005080544	⤷ Get Started Free
World Intellectual Property Organization (WIPO)	2004096978	⤷ Get Started Free
United States of America	9220737	⤷ Get Started Free
>Country	>Patent Number	>Estimated Expiration

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