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Last Updated: December 16, 2025

Claims for Patent: 8,603,480

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Summary for Patent: 8,603,480

Title:	Human cytomegalovirus neutralizing antibodies and use thereof
Abstract:	The invention relates to neutralizing antibodies, and antibody fragments thereof, having high potency in neutralizing hCMV, wherein said antibodies and antibody fragments are specific for one, or a combination of two or more, hCMV gene UL products. The invention also relates to immortalized B cells that produce, and to epitopes that bind to, such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies, antibody fragments, and epitopes in screening methods as well as in the diagnosis, prevention, and therapy of disease.
Inventor(s):	Antonio Lanzavecchia, Annalisa Macagno
Assignee:	Institute for Research in Biomedicine IRB
Application Number:	US13/003,603

Details for Patent 8,603,480

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Eusa Pharma (uk) Limited	SYLVANT	siltuximab	For Injection	125496	April 23, 2014	8,603,480	2029-07-15
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 8,603,480

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Country	Patent Number	Estimated Expiration
South Africa	201600335	⤷ Get Started Free
World Intellectual Property Organization (WIPO)	2010007533	⤷ Get Started Free
United States of America	9803000	⤷ Get Started Free
United States of America	9796772	⤷ Get Started Free
>Country	>Patent Number	>Estimated Expiration

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