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Last Updated: December 19, 2025

Claims for Patent: 8,343,508

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Summary for Patent: 8,343,508

Title:	Botulinum antitoxin compositions and methods
Abstract:	This invention provides botulinum antitoxin compositions and methods of production, and methods of treating animals and humans prophylactically and also those suspected of having contacted botulism toxin. The botulinum antitoxin is prepared by inoculating an animal with a monovalent botulinum toxoid and toxin. The animal's plasma is collected and purified at a high pH by affinity chromatography. The resulting monovalent immunoglobulins are de-speciated by digestion with pepsin. Monovalent antitoxins for all seven botulinum serotypes are then combined to produce a high titered heptavalent botulinum antitoxin composition.
Inventor(s):	Nicholas Pomato, Martin V. Haspel, Janet H. Ransom
Assignee:	Intracel Holdings LLC
Application Number:	US12/636,315

Details for Patent 8,343,508

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Emergent Biosolutions Canada Inc.	BAT	botulism antitoxin heptavalent (a, b, c, d, e, f, g) - (equine)	Solution	125462	March 22, 2013	8,343,508	2029-12-11
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 8,343,508

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Country	Patent Number	Estimated Expiration
World Intellectual Property Organization (WIPO)	2005030123	⤷ Get Started Free
United States of America	2010150934	⤷ Get Started Free
United States of America	2005042775	⤷ Get Started Free
>Country	>Patent Number	>Estimated Expiration

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