Claims for Patent: 8,252,277

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Summary for Patent: 8,252,277

Title:	Virulent oncolytic herpes simplex virus strains engineered to counter the innate host response
Abstract:	The present invention relates to an avirulent, oncolytic herpes simplex virus modified from a wild-type herpes simplex virus so that both γ134.5 genes of the virus have been deleted and each replaced with an interferon-resistance gene that is expressed as an immediate-early gene. The present invention also relates to a pharmaceutical composition that includes the modified herpes simplex virus of the present invention and a pharmaceutically acceptable vehicle for in situ administration to tumor cells. Also provided in the present invention are methods for killing tumor cells in a subject and for immunizing a subject against an infectious disease, cancer, or an autoimmune disease that involve administering to a subject the modified avirulent, oncolytic herpes simplex virus of the present invention.
Inventor(s):	Ian Mohr, Matthew Mulvey
Assignee:	New York University NYU
Application Number:	US12/767,973

Details for Patent 8,252,277

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Glaxosmithkline Llc	TANZEUM	albiglutide	For Injection	125431	April 15, 2014	⤷ Get Started Free	2030-04-27
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 8,252,277

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Country	Patent Number	Estimated Expiration
World Intellectual Property Organization (WIPO)	2006002394	⤷ Get Started Free
United States of America	8709397	⤷ Get Started Free
United States of America	7731952	⤷ Get Started Free
United States of America	2013034586	⤷ Get Started Free
>Country	>Patent Number	>Estimated Expiration

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