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Last Updated: April 23, 2024

Claims for Patent: 7,972,598

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Summary for Patent: 7,972,598

Title:	VEGF-binding fusion proteins and therapeutic uses thereof
Abstract:	Fusion proteins which bind and inhibit vascular endothelial growth factor (VEGF). The VEGF-binding fusion proteins are therapeutically useful for treating VEGF-associated conditions and diseases, and are specifically designed for local administration to specific organs, tissues, and/or cells.
Inventor(s):	Daly; Thomas J. (New City, NY), Fandl; James P. (LaGrangeville, NY), Papadopoulos; Nicholas J. (LaGrangeville, NY)
Assignee:	Regeneron Pharmaceuticals, Inc. (Tarrytown, NY)
Application Number:	12/623,869
Patent Claims:	1. A vascular endothelial growth factor (VEGF)-binding fusion protein, wherein the VEGF-binding fusion protein consists of R1, R2 and a multimerizing component (MC) wherein R1 is VEGF receptor component Ig domain 2 of Flt-1 and R2 is Ig domain 3 of Flk-1, and wherein the VEGF-binding fusion protein exhibits an affinity for VEGF of at least 1 pM.

Details for Patent 7,972,598

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Regeneron Pharmaceuticals, Inc.	EYLEA	aflibercept	Injection	125387	11/18/2011	⤷ Try a Trial	2039-03-29
Regeneron Pharmaceuticals, Inc.	EYLEA	aflibercept	Injection	125387	08/16/2018	⤷ Try a Trial	2039-03-29
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 7,972,598

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Country	Patent Number	Estimated Expiration
Argentina	044938	⤷ Try a Trial
Austria	293164	⤷ Try a Trial
Austria	417928	⤷ Try a Trial
Austria	427962	⤷ Try a Trial
Austria	486091	⤷ Try a Trial
>Country	>Patent Number	>Estimated Expiration

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