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Last Updated: December 17, 2025

Claims for Patent: 7,964,395

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Summary for Patent: 7,964,395

Title:	Modified vaccinia ankara virus variant and cultivation method
Abstract:	The present invention provides an attenuated virus, which is derived from Modified Vaccinia Ankara virus and characterized by the loss of its capability to reproductively replicate in human cell lines. It further describes recombinant viruses derived from this virus and the use of the virus, or its recombinants, as a medicament or vaccine. A method is provided for inducing an immune response in individuals who may be immune-compromised, receiving antiviral therapy, or have a pre-existing immunity to the vaccine virus. In addition, a method is provided for the administration of a therapeutically effective amount of the virus, or its recombinants, in a vaccinia virus prime/vaccinia virus boost inoculation regimen. The present invention relates to a method of virus amplification in primary cells which are cultivated in a serum free medium. Viruses produced by this method are advantageously free of any infectious agents comprised in animal sera.
Inventor(s):	Paul Chaplin, Paul Howley, Christine Meisinger-Henschel, Ingmar Rathe, Eva Felder, Karl Heller
Assignee:	Bavarian Nordic AS
Application Number:	US12/200,176

Details for Patent 7,964,395

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Bavarian Nordic A/s	JYNNEOS	smallpox and monkeypox vaccine, live, non-replicating	For Injection	125678	September 24, 2019	⤷ Get Started Free	2028-08-28
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 7,964,395

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Country	Patent Number	Estimated Expiration
World Intellectual Property Organization (WIPO)	2004022729	⤷ Get Started Free
World Intellectual Property Organization (WIPO)	03088994	⤷ Get Started Free
World Intellectual Property Organization (WIPO)	0242480	⤷ Get Started Free
United States of America	8673318	⤷ Get Started Free
>Country	>Patent Number	>Estimated Expiration

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