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Last Updated: December 17, 2025

Claims for Patent: 7,939,632

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Summary for Patent: 7,939,632

Title:	Proteolytically cleavable fusion proteins with high molar specific activity
Abstract:	The invention relates to therapeutic fusion proteins in which a coagulation factor is fused to a half-life enhancing polypeptide, and in which both are connected by a linker peptide that is proteolytically cleavable. The cleavage of such linkers liberates the coagulation factor from activity-compromising steric hindrance caused by the half-life enhancing polypeptide and thereby allows the generation of fusion proteins may show relatively high molar specific activity when tested in coagulation-related assays. Furthermore, the fact that the linker is cleavable can enhance the rates of inactivation and/or elimination after proteolytic cleavage of the peptide linker compared to the rates measured for corresponding therapeutic fusion proteins linked by the non-cleavable linker having the amino acid sequence GGGGGGV.
Inventor(s):	Hubert Metzner, Thomas Weimer, Stefan Schulte
Assignee:	CSL Behring GmbH Deutschland
Application Number:	US12/000,739

Details for Patent 7,939,632

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Csl Behring Lengnau Ag	IDELVION	coagulation factor ix (recombinant), albumin fusion protein	For Injection	125582	March 04, 2016	7,939,632	2027-12-17
Csl Behring Lengnau Ag	IDELVION	coagulation factor ix (recombinant), albumin fusion protein	For Injection	125582	May 30, 2018	7,939,632	2027-12-17
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 7,939,632

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Country	Patent Number	Estimated Expiration
World Intellectual Property Organization (WIPO)	2007144173	⤷ Get Started Free
United States of America	2020095567	⤷ Get Started Free
United States of America	2018119128	⤷ Get Started Free
United States of America	2016010074	⤷ Get Started Free
>Country	>Patent Number	>Estimated Expiration

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