Claims for Patent: 7,897,633

Summary for Patent: 7,897,633

Title:	Inhibitors of glutaminyl cyclase
Abstract:	The present invention relates to novel inhibitors of glutaminyl cyclase and combinations thereof for the treatment of neuronal disorders, especially Alzheimer\'s disease, Down Syndrome, Parkinson disease, Chorea Huntington, pathogenic psychotic conditions, schizophrenia, impaired food intake, sleep-wakefulness, impaired homeostatic regulation of energy metabolism, impaired autonomic function, impaired hormonal balance, impaired regulation, body fluids, hypertension, fever, sleep dysregulation, anorexia, anxiety related disorders including depression, seizures including epilepsy, drug withdrawal and alcoholism, neurodegenerative disorders including cognitive dysfunction and dementia.
Inventor(s):	Schilling; Stephan (Halle/Saale, DE), Buchholz; Mirko (Halle/Saale, DE), Niestroj; Andre (Sennewitz, DE), Heiser; Ulrich (Halle/Saale, DE), Demuth; Hans-Ulrich (Halle/Saale, DE)
Assignee:	Probiodrug AG (Halle-Saale, DE)
Application Number:	11/923,307
Patent Claims:	1. A compound of the formula 1 including all stereoisomers or pharmaceutically acceptable salts thereof: ##STR00103## wherein: A is: an alkyl chain, an alkenyl chain, an alkynyl chain; or a group selected from formulae (I) to (V): ##STR00104## wherein: R.sup.6, R.sup.7, R.sup.8, R.sup.9 and R.sup.10 are independently H or an alkyl chain, alkenyl chain, alkynyl chain, cycloalkyl, a carbocycle, aryl, heteroaryl, or a heterocycle; n and n.sup.1 are independently 1-5; m is 1-5; o is 0-4; B is a group selected from formulae (VI), (VIa), (VIb), (VII), (VIII), and (IX): ##STR00105## wherein: D and E independently represent an alkenyl chain, alkynyl chain, a cycloalkyl, carbocycle, aryl, -alkylaryl, heteroaryl, -alkylheteroaryl, acyl or a heterocycle; R.sup.15 and R.sup.16 are independently selected from the group consisting of H, a branched alkyl chain, an unbranched alkyl chain, a branched alkenyl chain, and an unbranched alkenyl chain; R.sup.17 and R.sup.18 are independently selected from the group consisting of H, an alkyl chain, an alkenyl chain, a alkynyl chain, a carbocycle, an aryl, a heteroaryl, and a heteroalkyl, or R.sup.17 and R.sup.18 can be connected to form a carbocycle with up to 6 ring atoms; Z is CH or N; X represents O or NR.sup.19; R.sup.19 is selected from the group consisting of alkyl, cycloalkyl, aryl, heteroaryl, -oxyalkyl, oxyaryl, carbonyl, amido hydroxy, NO.sub.2, NH.sub.2, and CN; and Y is O; with the provisos that: (i) If B is group (VI), then D is selected from the group consisting of 6-fluoro-4H-benzo[d][1,3]dioxin-8-yl, 3-(cyclopentyloxy)-4-(methoxy)-phenyl, 4-(heptyloxy)-phenyl, 4-(butoxy)-phenyl, 3,4-(dimethoxy)-phenyl, and 3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl; (ii) if X is NR.sup.19, then D is not acyl; (iii) if X is O, then -alkylheteroaryl is selected from the group consisting of pyridinylmethyl-, N-methyl-pyrrol-2-methyl-N-methyl-pyrrol-2-ethyl-, N-methyl-pyrrol-3-methyl-, N-methyl-pyrrol-3-ethyl-, 2-methyl-pyrrol-1-methyl-, 2-methyl-pyrrol-1-ethyl-, 3-methyl-pyrrol-1-methyl-, 3-methyl-pyrrol-1-ethyl-, 4-pyridino-methyl-, 4-pyridino-ethyl-, 2-(thiazol-2-yl)-ethyl-, tetrahydroisochinolinyl-methyl-, tetrahydroisochinolinyl-ethyl-, 2-ethyl-indol-1-methyl-, 2-ethyl-indol-1-ethyl-, 3-ethyl-indol-1-methyl-, 3-ethyl-indol-1-ethyl-, 4-methyl-pyridin-2-methyl-, 4-methyl-pyridin-2-yl-ethyl-, 4-methyl-pyridin-3-methyl, and 4-methyl-pyridin-3-ethyl; (iv) for formula (VII), if R.sup.17 and R.sup.18 form a carbocycle ring, then the carbocycle ring is not a 3 member carbocycle ring; (v) for formulas (VIII) and (IX), if Z.dbd.CH, then X is O; and with the proviso that the following compounds: ##STR00106## are excluded from formula 1. 2. The compound according to claim 1, wherein A is an unbranched C.sub.3 alkyl chain. 3. The compound according to claim 1, wherein A is a group of formula (I), (II) or (III), and n and n.sup.1 are each 1. 4. The compound according to any claim 1, wherein B is group (VI). 5. The compound according to claims 1, wherein B is group (VIa). 6. The compound according to claim 1, wherein X represents NR.sup.19. 7. The compound according to claim 1, wherein X represents O. 8. The compound according to claim 1, wherein D or E represents substituted phenyl. 9. The compound according to claim 1, wherein D or E represents 3,4-dimethoxyphenyl. 10. The compound according to claim 1 corresponding to either formula 1b: ##STR00107## wherein R.sup.1 and R.sup.2 are selected from: TABLE-US-00020 R.sup.1 R.sup.2 Cyano 3,4-(dimethoxy)-phenyl Cyano 2,4-(dimethoxy)-phenyl Cyano 3,5-(dimethoxy)-phenyl Cyano 2,3-dihydrobenzo[b][1,4]dioxin-7-yl Cyano Benzo[d][1,3]dioxol-6-yl Cyano 3-(methoxy)-phenyl Cyano 4-(ethoxy)-phenyl Cyano 4-(benzyloxy)-phenyl Cyano Phenyl Cyano 4-(methoxy)-phenyl Cyano 4-(acetyl)-phenyl Cyano 4-(nitro)-phenyl Cyano Benzyl Cyano Naphthalen-1-yl Cyano 4-(fluoro)-phenyl Cyano 4-(iodo)-phenyl Cyano 4-(bromo)-phenyl Cyano Cyclooctyl Cyano 4-(methyl)-phenyl Cyano 4-(methylthio)-phenyl Cyano 4-(ethyl)-phenyl Cyano 4-(dimethylamino)-phenyl Cyano Trityl Cyano (Benzo[d][1,3]dioxol-6yl)methyl Cyano (tetrahydrofuran-2yl)methyl Cyano 4-(trifluoromethyl)-phenyl Cyano (furan-2-yl)methyl Cyano 2-(morpholin-4-yl)-ethyl Cyano 2,3,4-(trimethoxy)-phenyl Cyano 4-(oxazol-5yl)-phenyl Cyano Pyridin-3-yl Cyano 4-(cyano)-phenyl Cyano 4-(trifluoromethoxy)-phenyl Cyano 4-(piperidinosulfonyl)-phenyl Cyano 4-(1H-pyrazol-1-yl)phenyl Methyl 3,4-(dimethoxy)-phenyl Cyano Cycloheptyl Cyano 3,4,5-(trimethoxy)-phenyl or formula 1c: ##STR00108## wherein R.sup.3 is selected from: TABLE-US-00021 R.sup.3 6-fluoro-4H-benzo[d][1,3]dioxin-8-yl 3-(cylopentyloxy)-4-(methoxy)-phenyl 4-(heptyloxy)-phenyl 4-(butoxy)-phenyl 3,4-(dimethoxy)-phenyl 3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl or a pharmaceutically acceptable salt or stereoisomers thereof. 11. A pharmaceutical composition comprising at least one compound according to claim 1 optionally in combination with a therapeutically acceptable carrier and/or excipient. 12. The pharmaceutical composition according to claim 11 for parenteral, enteral or oral administration. 13. A pharmaceutical composition comprising at least one compound according to claim 1 and at least one compound selected from the group consisting of PEP-inhibitors, LiCl, inhibitors of dipeptidyl aminopeptidases, preferably inhibitors of DP IV or DP IV-like enzymes, NPY-receptor ligands, NPY agonists, ACE inhibitors, PIMT enhancers, inhibitors of beta secretases, inhibitors of gamma secretases, inhibitors of neutral endopeptidase, PDE-4 inhibitors, MAO inhibitors, TNFalpha inhibitors, amyloid protein or amyloid peptide deposition inhibitors, sigma-1 receptor inhibitors and histamine H3 antagonists. 14. The pharmaceutical composition according to claim 13, wherein said inhibitor of DP IV/DP IV-like enzymes is selected from the group consisting of L-threo-isoleucyl pyrrolidine, L-allo-isoleucyl thiazolidine, L-allo-isoleucyl pyrrolidine and salts thereof, valine pyrrolidine, BMS-477118, CP-867534-01, LAF-237, PHX-1004, SSR-162369, SYR-322, TSL-225, FE-999011 GW-229A, 815541, K-579, MK-431, PT-100 and one of ##STR00109## 15. The pharmaceutical composition according to claim 13, wherein said NPY antagonist is selected from 3a,4,5,9b-tetrahydro-1h-benz[e]indol-2-yl amine, BIBP3226 and (R)--N2-(diphenylacetyl)-(R)--N-[1-(4-hydroxy-phenyl)ethyl] arginine amide. 16. The pharmaceutical composition according to claim 13, wherein said PEP-inhibitor is selected from the group consisting of chemical derivatives of proline or small peptides containing terminal prolines, benzyloxycarbonyl-prolyl-prolinal, N-terminal substituted L-proline, L-prolylpyrrolidine, substituted N-benzyloxycarbonyl (Z) dipeptides containing prolinal at the carboxy terminus, substituted thioprolines, substituted thiazolidines, substituted oxopyrrolidines, carboxy terminal modified prolines including fluorinated ketone derivatives, chloromethyl ketone derivatives of acyl-proline or acylpeptide-proline (Z-Gly-Pro-CH.sub.2Cl) and 2-acylpyrrolidine derivatives or wherein said PEP-inhibitor is selected from the group consisting of Fmoc-Ala-Pyrr-CN, Z-321, ONO-1603, JTP-4819, S-17092 and ##STR00110## 17. The pharmaceutical composition according to claim 13, wherein said ACE-inhibitor is SDZ ENA 713 (rivastigmine (+)-(S)--N-ethyl-3-[(1-dimethylamino)ethyl]-N-methylphenylcarbamate hydrogen tartrate. 18. The pharmaceutical composition according to claim 13, wherein said PDE-4 inhibitor is selected from the group consisting of Rolipram, CC-002, L-826141, Sch-351591 (D-4396), OS-0217, IBFB-130011, IBFB-150007, IBFB-130020, IBFB-140301, IC-485, VMX-554, VMX-565, MEM-1414, MEM-1018, MEM-1091, MEM-1145, Cl-1044, BHN, ZK-117137 and SB-207499 or analogs thereof. 19. The pharmaceutical composition according to claim 13, wherein said PIMT enhancer is a 10-aminoaliphatyl-dibenz[b,f] oxepine of the general formula ##STR00111## wherein alk is a divalent aliphatic radical, R is an amino group that is unsubstituted or mono- or di-substituted by monovalent aliphatic and/or araliphatic radicals or disubstituted by divalent aliphatic radicals, and R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each, independently of the others, hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl. 20. The pharmaceutical composition according to claim 13, wherein said gamma secretase inhibitor is ##STR00112## 21. The pharmaceutical composition according to claim 13, wherein said beta secretase inhibitor is ##STR00113## 22. The pharmaceutical composition according to claim 13, wherein said MAO inhibitor is ladostigil of the formula ##STR00114## 23. The pharmaceutical composition according to claim 13, wherein said histamine H3 antagonist is a compound selected from the group consisting of A-331440, A-349821, 3874-H1, UCL-2173, UCL-1470, DWP-302, GSK-189254A, GSK-207040A, cipralisant, GT-2203, 1S,2S)-2-(2-Aminoethyl)-1-(1H-imidazol-4-yl)cyclopropane, JNJ-5207852, NNC-0038-0000-1049, dual H1/H3, Sch-79687 and one of ##STR00115##

Details for Patent 7,897,633

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Jubilant Hollisterstier Llc	N/A	positive skin test control-histamine	Injection	103891	03/13/1924		2024-02-05