Claims for Patent: 7,776,844

Summary for Patent: 7,776,844

Title:	N-(phosphonoalkyl)-amino acids, derivatives thereof and compositions and methods of use
Abstract:	The present invention relates to an N-(phosphonoalkyl)-amino acid, a related compound or a derivative thereof, the N-(phosphonoalkyl)-amino acid, related compound or derivative thereof being in a form as a free acid, salt, partial salt, lactone, amide or ester, or in stereoisomeric or non-stereoisomeric form, other than N-(phosphonomethyl)-glycine or N,N-bis(phosphonomethyl)-glycine. Also included is a composition including an N-(phosphonoalkyl)-amino acid, a related compound or a derivative thereof in a form as a free acid, salt, partial salt, lactone, amide or ester, or in stereoisomeric or non-stereoisomeric form, and a cosmetically or pharmaceutically acceptable vehicle for topical or systemic administration to a mammalian subject, as well as a method of administering an effective amount of such a composition for alleviating or improving a condition, disorder, symptom or syndrome associated with at least one of a nervous, vascular, musculoskeletal or cutaneous system.
Inventor(s):	Yu; Ruey J. (Chalfont, PA), Van Scott; Eugene J. (Abington, PA)
Assignee:
Application Number:	12/428,906
Patent Claims:	1. A composition comprising an N-(phosphonoalkyl)-amino acid, a related compound or a derivative thereof in a form as a free acid, salt, partial salt, lactone, amide or ester, or in stereoisomeric or non-stereoisomeric form, and a cosmetically or pharmaceutically acceptable vehicle for topical or systemic administration to a mammalian subject for treatment of a cosmetic condition or dermatological disorder; wherein the N-(phosphonoalkyl)-amino acid, related compound or derivative thereof is N-(phosphonoalkyl)-proline or has the following formula: R.sub.1CH(NR.sub.2R.sub.3)(CH.sub.2).sub.mCOR.sub.4 wherein R.sub.1 is H, and alkyl group having 1 to 19 carbon atoms, an aryl group having 6 to 19 carbon atoms or an aralkyl group having 7 to 19 carbon atoms; and R.sub.1 can also carry --OH, --SH, --SCH.sub.3, --NH.sub.2, --NR.sub.2R.sub.3, --COR.sub.4, --NHCONH.sub.2, --NHC(.dbd.NR.sub.2)NH.sub.2, imidazole, pyrrolidine or other heterocyclic group; m is an integer from 0 to 5; R.sub.2 is a phosphonoalkyl group having a formula (HO).sub.2PO(CH.sub.2).sub.n--; R.sub.3 is H or a phosphonoalkyl group having a formula (HO).sub.2PO(CH.sub.2).sub.n--; n is an integer from 1 to 9; R.sub.4 is --NH.sub.2 or --OR.sub.5, R.sub.5 is H, and alkyl group having 1 to 19 carbon atoms, an aryl group having 6 to 19 carbon atoms or an aralkyl group having 7 to 19 carbon atoms; and the H attached to any carbon atom can be substituted by I, F, Cl, Br, OH or an alkoxy group having 1 to 9 carbon atoms; and wherein the N-(phosphonoalkyl)-amino acid, related compound or derivative thereof is in a form as a free acid, salt, partial salt, lactone, amide or ester, or in stereoisomeric or non-stereoisomeric form. 2. The composition of claim 1, wherein the related compound or derivative is an N,N-bis(phosphonoalkyl)-amino acid or an N,N'-bis(phosphonoalkyl)-amino acid. 3. The composition of claim 2, wherein the related compound or derivative is an N,N-bis(phosphonomethyl)-amino acid or an N,N'-bis(phosphonomethyl)-amino acid. 4. The composition of claim 3, wherein the N,N-bis(phosphonomethyl)-amino acid or N,N'-bis(phosphonomethyl)-amino acid in a form as a free acid, salt, partial salt, lactone, amide or ester, or in stereoisomeric or non-stereoisomeric form, is selected from the group consisting of N,N-bis(phosphonomethyl)-alanine; N,N-bis(phosphonomethyl)-arginine; N,N-bis(phosphonomethyl)-aspartic acid; N,N-bis(phosphonomethyl)-asparagine; N,N-bis(phosphonomethyl)-cysteine; N,N-bis(phosphonomethyl)-glycine; N,N-bis(phosphonomethyl)-glutamic acid; N,N-bis(phosphonomethyl)-glutamine; N,N-bis(phosphonomethyl)-histidine; N,N-bis(phosphonomethyl)-isoleucine; N,N-bis(phosphonomethyl)-leucine; N,N-bis(phosphonomethyl)-lysine; N,N-bis(phosphonomethyl)-methionine; N,N-bis(phosphonomethyl)-phenylalanine; N,N-bis(phosphonomethyl)-serine; N,N-bis(phosphonomethyl)-threonine; N,N-bis(phosphonomethyl)-tryptophan; N,N-bis(phosphonomethyl)-tyrosine; N,N-bis(phosphonomethyl)-valine; N,N'-bis(phosphonomethyl)-arginine; N,N'-bis(phosphonomethyl)-histidine; N,N'-bis(phosphonomethyl)-lysine and N,N'-bis(phosphonomethyl)-tryptophan. 5. The composition of claim 3, wherein the related compound or compound derived therefrom in a form as a free acid, salt, partial salt, lactone, amide or ester, or in stereoisomeric or non-stereoisomeric form, is selected from the group consisting of N,N-bis(phosphonomethyl)-.beta.-alanine; N,N-bis(phosphonomethyl)-.gamma.-aminobutanoic acid; N,N-bis(phosphonomethyl)-.beta.-aminoisobutanoic acid; N,N-bis(phosphonomethyl)-anserine; N,N-bis(phosphonomethyl)-aminolevulinic acid; N,N-bis(phosphonomethyl)-carnosine; N,N-bis(phosphonomethyl)-canaline; N,N-bis(phosphonomethyl)-canavanine; N,N-bis(phosphonomethyl)-citrulline; N,N-bis(phosphonomethyl)-creatine; N,N-bis(phosphonomethyl)-creatinine; N,N-bis(phosphonomethyl)-cysteine sulfinic acid; N,N-bis(phosphonomethyl)-cystine; N,N-bis(phosphonomethyl)-cycloserine; N,N-bis(phosphonomethyl)-dopa {N,N-bis(phosphonomethyl)-3,4-dihydroxyphenylalanine}; N,N-bis(phosphonomethyl)-dopamine(hydroxytyramine); N,N-bis(phosphonomethyl)-ethionine; N,N-bis(phosphonomethyl)-glutathione; N,N-bis(phosphonomethyl)-guanidinoacetic acid; N,N-bis(phosphonomethyl)-3-guanidinopropanoic acid; N,N-bis(phosphonomethyl)-4-guanidinobutanoic acid; N,N-bis(phosphonomethyl)-homocamosine; N,N-bis(phosphonomethyl)-homocysteine; N,N-bis(phosphonomethyl)-homoserine; N,N-bis(phosphonomethyl)-4-hydroxyphenylglycine; N,N-bis(phosphonomethyl)-hydroxyglutamic acid; N,N-bis(phosphonomethyl)-hydroxylysine; N,N-bis(phosphonomethyl)-hydroxyproline; N,N-bis(phosphonomethyl)-hypusine; N,N-bis(phosphonomethyl)-homoarginine; N,N-bis(phosphonomethyl)-homocitrulline; N,N-bis(phosphonomethyl)-homocystine; N,Nbis(phosphonomethyl)-homophenylalanine; N,N-bis(phosphonomethyl)-homotryptophan; N,N-bis(phosphonomethyl)-hydroxylysine; N,N-bis(phosphonomethyl)-hydroxyarginine; N,N-bis(phosphonomethyl)-hydroxyhomoarginine; N,N-bis(phosphonomethyl)-hydroxycitrulline; N,N-bis(phosphonomethyl)-hydroxyomithine; N,N-bis(phosphonomethyl)-hydroxyvaline; N,N-bis(phosphonomethyl)-indospicine; N,N-bis(phosphonomethyl)-methoxinine; N,N-bis(phosphonomethyl)-methylarginine; N,N-bis(phosphonomethyl)-methylhistidine; N,N-bis(phosphonomethyl)-methyllysine; N,N-bis(phosphonomethyl)-methylornithine; N,N-bis(phosphonomethyl)-methylserine; N,N-bis(phosphonomethyl)-norvaline; N,N-bis(phosphonomethyl)-ornithine; N,N-bis(phosphonomethyl)-oxalysine; N,N-bis(phosphonomethyl)-penicillamine(N-phosphonomethyl-dimethylcysteine- ); N,N-bis(phosphonomethyl)-phenylglycine; N,N-bis(phosphonomethyl)-3-phenylserine; N,N-bis(phosphonomethyl)-sarcosine (N-phosphonomethyl-N-methyl-glycine); N,N-bis(phosphonomethyl)-serotonin (N-phosphonomethyl-hydroxytryptamine); N,N-bis(phosphonomethyl)-taurine; N,N-bis(phosphonomethyl)-tryptamine; N,N-bis(phosphonomethyl)-tyramine and N,N'-bis(phosphonomethyl)-ornithine. 6. The composition of claim 1, wherein the phosphonoalkyl of the N-(phosphonoalkyl)-amino acid compound, related compound or compound derived therefrom is selected from the group consisting of phosphonomethyl, phosphonoethyl, phosphonopropyl, phosphonoisopropyl, phosphonobutyl, phosphonoisobutyl, phosphonopentyl, phosphonoisopentyl, phosphonooctyl and phosphonoisooctyl. 7. The composition of claim 1, wherein the compound is an N-(phosphonoalkyl)-amino acid. 8. The composition of claim 1, wherein the compound is an N-(phosphonomethyl)-amino acid. 9. The composition of claim 8, wherein the N-(phosphonomethyl)-amino acid in a form as a free acid, salt, partial salt, lactone, amide or ester, or in a stereoisomeric or non-stereoisomeric form, is selected from the group consisting of N-(phosphonomethyl)-alanine, N-(phosphonomethyl)-arginine, N-(phosphonomethyl)-asparagine, N-(phosphonomethyl)-aspartic acid, N-(phosphonomethyl)-cysteine, N-(phosphonomethyl)-glutamic acid, N-(phosphonomethyl)-glutamine, N-(phosphonomethyl)-glycine, N-(phosphonomethyl)-histidine, N-(phosphonomethyl)-isoleucine, N-(phosphonomethyl)-leucine, N-(phosphonomethyl)-lysine, N-(phosphonomethyl)-methionine, N-(phosphonomethyl)-phenylalanine, N-(phosphonomethyl)-proline, N-(phosphonomethyl)-serine, N-(phosphonomethyl)-threonine, N-(phosphonomethyl)-tryptophan, N-(phosphonomethyl)-tyrosine and N-(phosphonomethyl)-valine. 10. The composition of claim 1, wherein the N-(phosphonoalkyl)-amino acid compound, related compound or compound derived therefrom in a form as a free acid, salt, partial salt, lactone, amide or ester, or in stereoisomeric or non-stereoisomeric form, is selected from the group consisting of N-(phosphonomethyl)-alanine, N-(phosphonomethyl)-aminobutanoic acid, N-(phosphonomethyl)-aminoisobutanoic acid, N-(phosphonomethyl)-anserine, N-(phosphonomethyl)-aminolevulinic acid, N-(phosphonomethyl)-carnosine, N-(phosphonomethyl)-canaline, N-(phosphonomethyl)-canavanine, N-(phosphonomethyl)-citrulline, N-(phosphonomethyl)-creatine, N-(phosphonomethyl)-creatinine, N-(phosphonomethyl)-cysteine sulfinic acid, N-(phosphonomethyl)-cystine, N-(phosphonomethyl)-cycloserine, N-(phosphonomethyl)-dopa[N-(phosphonomethyl)-3,4-dihydroxyphenylalanine], N-(phosphonomethyl)-dopamine(hydroxytyramine), N-(phosphonomethyl)-ethionine, N-(phosphonomethyl)-glutathione, N-(phosphonomethyl)-guanidinoacetic acid, N-(phosphonomethyl)-3-guanidinopropanoic acid, N-(phosphonomethyl)-4-guanidinobutanoic acid, N-(phosphonomethyl)-homocarnosine, N-(phosphonomethyl)-homocysteine, N-(phosphonomethyl)-homoserine, N-(phosphonomethyl)-4-hydroxyphenylglycine, N-(phosphonomethyl)-hydroxyglutamic acid, N-(phosphonomethyl)-hydroxylysine, N-(phosphonomethyl)-hydroxyproline, N-(phosphonomethyl)-hypusine, N-(phosphonomethyl)-homoarginine, N-(phosphonomethyl)-homocitrulline, N-(phosphonomethyl)-homocystine, N-(phosphonomethyl)-homophenylalanine, N-(phosphonomethyl)-homotryptophan, N-(phosphonomethyl)-hydroxylysine, N-(phosphonomethyl)-hydroxyarginine, N(phosphonomethyl)-hydroxyhomoarginine, N-(phosphonomethyl)-hydroxycitrulline, N-(phosphonomethyl)-hydroxyomithine, N-(phosphonomethyl)-hydroxyvaline, N-(phosphonomethyl)-indospicine, N-(phosphonomethyl)-methoxinine, N-(phosphonomethyl)-methylarginine, N-(phosphonomethyl)-methylhistidine, N-(phosphonomethyl)-methyllysine, N-(phosphonomethyl)-methylornithine, N-(phosphonomethyl)-methylserine, N-(phosphonomethyl)-norvaline, N-(phosphonomethyl)-ornithine, N-(phosphonomethyl)-oxalysine, N-(phosphonomethyl)-penicillamine(N-phosphonomethyl-dimethylcysteine), N-(phosphonomethyl)-phenylglycine, N-(phosphonomethyl)-3-phenylserine, N-(phosphonomethyl)-sarcosine (N-phosphonomethyl-N-methyl-glycine), N-(phosphonomethyl)-serotonin (N-phosphonomethyl-hydroxytryptamine), N-(phosphonomethyl)-taurine, N-(phosphonomethyl)-tryptamine and N-(phosphonomethyl)-tyramine. 11. The composition of claim 1, wherein the N-(phosphonoalkyl)-amino acid compound, related compound or compound derived therefrom in a form as a free acid, salt, partial salt, lactone, amide or ester, or in stereoisomeric or non-stereoisomeric form, is selected from the group consisting of N-(phosphonomethyl)-asparagine, N-(phosphonomethyl)-asparaginamide, N-(phosphonomethyl)-aminobutanoic acid, N-(phosphonomethyl)-arginine, N-(phosphonomethyl)-argininamide, N-(phosphonomethyl)-arginine ethyl ester, N-(phosphonomethyl)-creatine, N-(phosphonomethyl)-creatinine, N-(phosphonomethyl)-cysteine, N-(phosphonomethyl)-glutamic acid, N-(phosphonomethyl)-glutamic acid diethyl ester, N-(phosphonomethyl)-glutamine, N-(phosphonomethyl)-glutaminamide, N-(phosphonomethyl)-glutamine ethyl ester, N-(phosphonomethyl)-glutathione, N-(phosphonomethyl)-glycine, N-(phosphonomethyl)-glycinamide, N-(phosphonomethyl)-glycine ethyl ester, N-(phosphonomethyl)-glycine propyl ester, N-(phosphonomethyl)-glycine isopropyl ester, N-(phosphonomethyl)-4-hydroxyphenylglycine, N-(phosphonomethyl)-lysine, N-(phosphonomethyl)-lysinamide, N-(phosphonomethyl)-lysine ethyl ester, N-(phosphonomethyl)-ornithine, N-(phosphonomethyl)-proline, N-(phosphonomethyl)-prolinamide, N-(phosphonomethyl)-proline ethyl ester, N-(phosphonomethyl)-proline propyl ester, N-(phosphonomethyl)-proline isopropyl ester, N-(phosphonomethyl)-serine, N-(phosphonomethyl)-tyrosine and N-(phosphonomethyl)-tyramine. 12. The composition of claim 1, wherein the composition further comprises a cosmetic or pharmaceutical agent. 13. The composition of claim 12, wherein the cosmetic or pharmaceutical agent is selected from the group consisting of hydroxyacids, ketoacids and related compounds; phenyl alpha acyloxyalkanoic acids and derivatives; N-acyl-aldosamines, N-acylamino acids and related N-acyl compounds; local analgesics and anesthetics; anti-acne agents; anti-bacterial agents; anti-yeast agents; anti-fungal agents; anti-viral agents; anti-infective agents; anti-dandruff agents; anti-dermatitis agents; anti-eczema agents; anti-histamine agents; anti-pruritic agents; anti-emetics; anti-motion sickness agents; anti-inflammatory agents; anti-hyperkeratotic agents; antiperspirants; anti-psoriatic agents; anti-rosacea agents; anti-seborrheic agents; hair conditioners and hair treatment agents; anti-aging and anti-wrinkle agents; anti-anxiety agents; anti-convulsant agents; anti-depressant agents; sunblock and sunscreen agents; skin lightening agents; depigmenting agents; astringents; cleansing agents; corn, callus or wart removing agents; skin plumping agents; skin volumizing agents; skin firming agents; matrix metalloproteinase (MMP) inhibitors; topical cardiovascular agents; wound-healing agents; gum disease or oral care agents; amino acids; peptides; dipeptides; tripeptides; glutathione and its derivatives; oligopeptides; polypeptides; carbohydrates; aminocarbohydrates; vitamins; corticosteroids; tanning agents; hormones and retinoids. 14. The composition of claim 12, wherein the cosmetic or pharmaceutical agent as stated or as free base, free acid, ester, amide, lactone or salt form is selected from the group consisting of: abacavir, abciximab, acamprosate, acarbose, acebutolol, acetaminophen, acetaminosalol, acetazolamide, acetic acid, acetohydroxamic acid, N-acetylcysteine and its esters, N-acetylglutathione and its esters, acitretin, aclometasone dipropionate, acrivastine, acthrel, actidose, actigall, acyclovir, adalimumab, adapalene, adefovir dipivoxil, adenosine, agalsidase, albendazole, albumin, albuterol, aldesleukin, alefacept, alemtuzumab, alendronate, alfuzosin, alitretinoin, allantoin, allium, allopurinol, alloxanthine, almotriptan, alosetron, alpha tocopheral, alpha.sub.1-proteinase, alprazolam, alprenolol, alprostadil, alteplase, altretamine, aluminum acetate, aluminum chloride, aluminum chlorohydroxide, aluminum hydroxide, amantadine, amifostine, amiloride, aminacrine, amino acid, aminobenzoate, p-aminobenzoic acid, aminocaproic acid, aminohippurate, aminolevulinic acid, aminosalicylic acid, amiodarone, amitriptyline, amlodipine, amocarzine, amodiaquin, amorolfine, amoxapine, amoxicillin, amphetamine, amphotericin, ampicillin, amprenavir, anagrelide, anakinra, anastrozole, anisindione, anthralin, antihemophilic, antithrombin, anti-thymocyte, antivenin, apomorphine, aprepitant, aprotinin, arbutin, argatroban, aripiprazole, arnica, ascorbic acid and its esters, ascorbyl palmitate, aspirin, atazanavir, atenolol, atomoxetine, atorvastatin, atovaquone, atropine, azathioprine, azelaic acid, azelastine, azithromycin, baclofen, bacitracin, balsalazide, balsam, basiliximab, beclomethasone dipropionate, bemegride, benazepril, bendroflumethiazide, benzocaine, benzonatate, benzophenone, benzoyl peroxide, benztropine, bepridil, beta carotene, betamethasone dipropionate, betamethasone valerate, betaxolol, bethanechol, bevacizumab, bexarotene, bicalutamide, bimatoprost, bioflavonoids, biotin, biperiden, bisacodyl, bisoprolol, bivalirudin, bortezomib, bosentan, botulinum, brimonidine, brinzolamide, bromocriptine, brompheniramine, budesonide, bumetanide, bupivacaine, buprenorphine, bupropion, burimamide, buspirone, busulfan, butabarbital, butalbital, butenafine, butoconazole, butorphanol, butyl aminobenzoate, cabergoline, caffeic acid, caffeine, calcipotriene, calcitonin-salmon, calcitriol, calfactant, camellia sinensis, camphor, candesartan cilexetil, capecitabine, capreomycin, capsaicin, captopril, carbamazepine, carbamide peroxide, carbidopa, carbinoxamine, cefditoren pivoxil, cefepime, cefpodoxime proxetil, celecoxib, cetirizine, cevimeline, chitosan, chlordiazepoxide, chlorhexidine, chloroquine, chlorothiazide, chloroxylenol, chlorpheniramine, chlorpromazine, chlorpropamide, ciclopirox, cilostazol, cimetidine, cinacalcet, ciprofloxacin, citalopram, citric acid, cladribine, clarithromycin, clemastine, clindamycin, clioquinol, clobetasol propionate, clocortolone pivalate, clomiphene, clonidine, clopidogrel, clotrimazole, clozapine, coal tar, coal tar extracts (LCD), codeine, cromolyn, crotamiton, cyclizine, cyclobenzaprine, cycloserine, cytarabine, dacarbazine, dalfopristin, dapsone, daptomycin, daunorubicin, deferoxamine, dehydroepiandrosterone, delavirdine, desipramine, desloratadine, desmopressin, desoximetasone, dexamethasone, dexmedetomidine, dexmethylphenidate, dexrazoxane, dextroamphetamine, diazepam, diclofenac, dicyclomine, didanosine, dihydrocodeine, dihydromorphine, diltiazem, 6,8-dimercaptooctanoic acid (dihydrolipoic acid), diphenhydramine, diphenoxylate, dipyridamole, disopyramide, dobutamine, dofetilide, dolasetron, donepezil, dopa esters, dopamide, dopamine, dorzolamide, doxepin, doxorubicin, doxycycline, doxylamine, doxepin, duloxetine, dyclonine, econazole, efalizumab, eflomithine, eletriptan, emtricitabine, enalapril, ephedrine, epinephrine, epinine, epirubicin, eptifibatide, ergotamine, erythromycin, escitalopram, esmolol, esomeprazole, estazolam, estradiol, etanercept, ethacrynic acid, ethinyl estradiol, etidocaine, etomidate, famciclovir, famotidine, felodipine, fentanyl, ferulic acid, fexofenadine, flecamide, fluconazole, flucytosine, fluocinolone acetonide, fluocinonide, 5-fluorouracil, fluoxetine, fluphenazine, flurazepam, fluticasone propionate, fluvoxamine, formoterol, furosemide, galactarolactone, galactonic acid, galactonolactone, galantamine, gatifloxacin, gefitinib, gemcitabine, gemifloxacin, glucarolactone, gluconic acid, gluconolactone, glucuronic acid, glucuronolactone, glycolic acid, griseofulvin, guaifenesin, guanethidine, N-guanylhistamine, haloperidol, haloprogin, hexylresorcinol, homatropine, homosalate, hydralazine, hydrochlorothiazide, hydrocortisone, hydrocortisone 21-acetate, hydrocortisone 17-butyrate, hydrocortisone 17-valerate, hydrogen peroxide, hydromorphone, hydroquinone, hydroquinone monoether, hydroxyzine, hyoscyamine, hypoxanthine, ibuprofen, ichthammol, idarubicin, imatinib, imipramine, imiquimod, indinavir, indomethacin, infliximab, irbesartan, irinotecan, isoetharine, isoproterenol, itraconazole, kanamycin, ketamine, ketanserin, ketoconazole, ketoprofen, ketotifen, kojic acid, labetalol, lactic acid, lactobionic acid, lamivudine, lamotrigine, lansoprazole, letrozole, leuprolide, levalbuterol, levofloxacin, lidocaine, linezolid, lobeline, loratadine, loperamide, losartan, loxapine, lysergic diethylamide, mafenide, malic acid, maltobionic acid, mandelic acid, maprotiline, mebendazole, mecamylamine, meclizine, meclocycline, memantine, menthol, meperidine, mepivacaine, mequinol, mercaptopurine, mescaline, metanephrine, metaproterenol, metaraminol, metformin, methadone, methamphetamine, methotrexate, methoxamine, methyldopa esters, methyldopamide, 3,4-methylenedioxymethamphetamine, methyllactic acid, methyl nicotinate, methylphenidate, methyl salicylate, metiamide, metolazone, metoprolol, metronidazole, mexiletine, miconazole, midazolam, midodrine, miglustat, minocycline, minoxidil, mirtazapine, mitoxantrone, moexiprilat, molindone, monobenzone, morphine, moxifloxacin, moxonidine, mupirocin, nadolol, naftifine, nalbuphine, nalmefene, naloxone, naproxen, nefazodone, nelfinavir, neomycin, nevirapine, nicardipine, nicotine, nifedipine, nimodipine, nisoldipine, nitrofurantoin, nizatidine, norepinephrine, nystatin, octopamine, octreotide, octyl methoxycinnamate, octyl salicylate, ofloxacin, olanzapine, olmesartan medoxomil, olopatadine, omeprazole, ondansetron, oxiconazole, oxotremorine, oxybenzone, oxybutynin, oxycodone, oxymetazoline, padimate O, palonosetron, pantothenic acid, pantoyl lactone, paroxetine, pemoline, penciclovir, penicillamine, penicillins, pentazocine, pentobarbital, pentostatin, pentoxifylline, pergolide, perindopril, permethrin, phencyclidine, phenelzine, pheniramine, phenmetrazine, phenobarbital, phenol, phenoxybenzamine, phentolamine, phenylephrine, phenylpropanolamine, phenyloin, physostigmine, pilocarpine, pimecrolimus, pimozide, pindolol, pioglitazone, pipamazine, piperonyl butoxide, pirenzepine, podofilox, povidone iodine, pramipexole, pramoxine, prazosin, prednisone, prenalterol, prilocalne, procainamide, procaine, procarbazine, promazine, promethazine, promethazine propionate, propafenone, propoxyphene, propranolol, propylthiouracil, protriptyline, pseudoephedrine, pyrethrin, pyrilamine, pyrimethamine, quetiapine, quinapril, quinethazone, quinidine, quinupristin, rabeprazole, reserpine, resorcinol, retinal, 13-cis retinoic acid, retinoic acid, retinol, retinyl acetate, retinyl palmitate, ribavirin, ribonic acid, ribonolactone, rifampin, rifapentine, rifaximin, riluzole, rimantadine, risedronic acid, risperidone, ritodrine, rivastigmine, rizatriptan, ropinirole, ropivacaine, salicylamide, salicylic acid, salmeterol, scopolamine, selegiline, selenium sulfide, serotonin, sertaconazole, sertindole, sertraline, shale tar, sibutramine, sildenafil, sotalol, streptomycin, strychnine, sulconazole, sulfacetamide, sulfabenz, sulfabenzamide, sulfabromomethazine, sulfacetamide (sodium sulfacetamide), sulfachlorpyridazine, sulfacytine, sulfadiazine, sulfadimethoxine, sulfadoxine, sulfaguanole, sulfalene, sulfamethizole, sulfamethoxazole, sulfanilamide, sulfapyrazine, sulfapyridine, sulfasalazine, sulfasomizole, sulfathiazole, sulfisoxazole, sulfur, tacrolimus, tadalafil, tamsulosin, tartaric acid, tazarotene, tegaserod, telithromycin, telmisartan, temozolomide, tenofovir disoproxil, terazosin, terbinafine, terbutaline, terconazole, terfenadine, tetracaine, tetracycline, tetrahydrozoline, thalidomide, theobromine, theophylline, thiabendazole, thioctic acid (lipoic acid), thioridazine, thiothixene, thymol, tiagabine, timolol, timidazole, tioconazole, tirofiban, tizanidine, tobramycin, tocamide, tolazoline, tolbutamide, tolnaftate, tolterodine, tramadol, tranylcypromine, trazodone, triameinolone acetonide, triamcinolone diacetate, triamcinolone hexacetonide, triamterene, triazolam, triclosan, triflupromazine, trimethoprim, trimipramine, tripelennamine, triprolidine, tromethamine, tropic acid, tyramine, undecylenic acid, urea, urocanic acid, ursodiol, valacyclovir, vardenafil, venlafaxine, verapamil, vitamin E acetate, voriconazole, warfarin, wood tar, xanthine, zafirlukast, zaleplon, zinc pyrithione, ziprasidone, zolmitriptan and zolpidem. 15. The composition of claim 1, wherein the treatment of a cosmetic condition or dermatological disorder is treatment of a cosmetic condition of dermatological disorder selected from the group consisting of disturbed keratinization; changes associated with intrinsic and extrinsic aging; acne; rosacea; age spots; blemished skin; blotches; cellulite; dermatoses; dermatitis; skin, nail and hair infections; dandruff; dryness or looseness of skin, nail and hair; xerosis; eczema; elastosis; herpes; hyperkeratosis; hyperpigmented skin; ichtyosis; keratoses; lentigines; melasmas; mottled skin; pseudofolliculitis barbae; photoaging and photodamage; pruritus; psoriasis; skin lines; stretch marks; thinning of skin, nail plate and hair; warts; wrinkles; breakdown, defective synthesis or repair of dermal components; abnormal or diminished synthesis of collagen, glycosaminoglycans, proteoglycans or elastin, diminished levels of collagen, glycosaminoglycans, proteoglycans or elastin in the dermis; uneven skin tone; uneven and rough surface of skin, nail and hair; loss or reduction of skin, nail and hair resiliency, elasticity and recoilability; laxity; lack of skin, nail and hair lubricants and luster; fragility and splitting of nail and hair, yellowing skin; reactive, irritating or telangiectatic skin; dull and older-looking skin, nail and hair; or wherein the treatment of a cosmetic condition or dermatological disorder is for general care of skin, nail and hair; to improve skin texture and pores, flakiness and redness; to make skin soft, smooth, fresh, balanced, visibly clear, even-toned and brighter; to increase skin fullness and plumpness; for skin bleach and lightning; or wound healing. 16. The composition of claim 1, wherein the N-(phosphonoalkyl)-amino acid is N-(phosphonomethyl)-glycine and the composition is used for systemic administration to the mammalian subject for treatment of a cosmetic condition or dermatological disorder. 17. The composition of claim 16, wherein the cosmetic condition or dermatological disorder is selected from the group consisting of disturbed keratinization; acne; hyperkeratosis and ichthyosis.

Details for Patent 7,776,844

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Ferring Pharmaceuticals Inc.	ACTHREL	corticorelin ovine triflutate	For Injection	020162	05/23/1996		2026-01-10
Bayer Healthcare Pharmaceuticals Inc.	TRASYLOL	aprotinin	Injection	020304	12/29/1993		2026-01-10
Ony Biotech Inc.	INFASURF	calfactant	Suspension	020521	07/01/1998		2026-01-10
Ony Biotech Inc.	INFASURF	calfactant	Suspension	020521	12/12/2002		2026-01-10
Ony Biotech Inc.	INFASURF	calfactant	Suspension	020521			2026-01-10
Merck Sharp & Dohme Corp.	LACTRODECTUS MACTANS	antivenin (latrodectus mactans)	For Injection	101062	02/13/1936		2026-01-10