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Last Updated: December 16, 2025

Claims for Patent: 7,670,597

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Summary for Patent: 7,670,597

Title:	Ex vivo and in vivo expression of the thrombomodulin gene for the treatment of cardiovascular and peripheral vascular diseases
Abstract:	The present invention relates to methods and compositions for treatment of cardiovascular and peripheral vascular diseases using ex vivo and in vivo gene delivery technologies. One aspect of the present invention relates to a method for treating a vascular disease by introducing a DNA sequence encoding a TM protein or its variant into a segment of a blood vessel ex vitro using a gutless adenovirus vector. Another aspect of the present invention is to provide a method to deliver a gutless adenovirus vector carrying a DNA sequence encoding a TM protein or its variant using a stent.
Inventor(s):	Lakshman R. Sehgal, Jonathan Wong
Assignee:	Biovec LLC
Application Number:	US11/464,712

Details for Patent 7,670,597

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Eusa Pharma (uk) Limited	SYLVANT	siltuximab	For Injection	125496	April 23, 2014	7,670,597	2026-08-15
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 7,670,597

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Country	Patent Number	Estimated Expiration
World Intellectual Property Organization (WIPO)	2010085262	⤷ Get Started Free
World Intellectual Property Organization (WIPO)	2008088358	⤷ Get Started Free
World Intellectual Property Organization (WIPO)	2004050844	⤷ Get Started Free
United States of America	9388427	⤷ Get Started Free
>Country	>Patent Number	>Estimated Expiration

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