Claims for Patent: 7,491,517

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Summary for Patent: 7,491,517

Title:	Method of producing meningococcal meningitis vaccine for Neisseria meningitidis serotypes A,C,Y, and W-135
Abstract:	Methods for producing quadrivalent meningococcal meningitis polysaccharide and conjugate vaccines for serotypes A, C, Y and W-135 disclosed. Neisseria meningitidis fastidious medium was designed to maximize the yield of capsular polysaccharides and generate minimal cellular biomass and endotoxin in a short duration of fermentation. The crude polysaccharides are isolated, purified, and mechanically depolymerized by sonication. These purified polysaccharides were found in human clinical trials to be safe and immunogenic against meningococcal disease caused by N. meningitidis A, C, Y and W-135 serogroups in sub-Saharan Africa. In the preferred embodiment, the polysaccharides are conjugated to carrier proteins of diphtheria or tetanus toxiod to an average molecular size of 5100 to 9900 Daltons and provide broad spectrum protection to humans of all ages. Accelerated polysaccharide production and the efficacy of the resulting vaccine are demonstrated.
Inventor(s):	Jeeri R Reddy
Assignee:	Jn Medical Corp
Application Number:	US11/680,471

Details for Patent 7,491,517

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Sanofi Pasteur Inc.	MENACTRA	meningococcal (groups a, c, y and w-135) polysaccharide diphtheria toxoid conjugate vaccine	For Injection	125089	January 14, 2005	⤷ Get Started Free	2027-02-28
Pfizer Ireland Pharmaceuticals	PENBRAYA	meningococcal groups a, b, c, w and y vaccine	Injection	125770	October 20, 2023	⤷ Get Started Free	2027-02-28
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 7,491,517

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Country	Patent Number	Estimated Expiration
South Africa	200900182	⤷ Get Started Free
World Intellectual Property Organization (WIPO)	2008011201	⤷ Get Started Free
United States of America	8129147	⤷ Get Started Free
United States of America	2017157235	⤷ Get Started Free
>Country	>Patent Number	>Estimated Expiration

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