Last Updated: April 23, 2026

Claims for Patent: 7,482,015

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Summary for Patent: 7,482,015

Title:	Optimized expression of HPV 45 L1 in yeast
Abstract:	Synthetic DNA molecules encoding the HPV45 L1 protein are provided. Specifically, the present invention provides polynucleotides encoding HPV45 L1 protein, wherein said polynucleotides have been codon-optimized for high level expression in a yeast cell. The synthetic molecules may be used to produce HPV45 virus-like particles (VLPs), and to produce vaccines and pharmaceutical compositions comprising the HPV45 VLPs. The vaccines of the present invention provide effective immunoprophylaxis against papillomavirus infection through neutralizing antibody and cell-mediated immunity.
Inventor(s):	Janine T. Bryan, Michelle K. Brownlow, Loren D. Schultz, Kathrin U. Jansen
Assignee:	Merck Sharp and Dohme LLC
Application Number:	US11/805,453

Details for Patent 7,482,015

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Llc	GARDASIL 9	human papillomavirus 9-valent vaccine, recombinant	Injection	125508	December 10, 2014	⤷ Start Trial	2027-05-23
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 7,482,015

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Country	Patent Number	Estimated Expiration
Argentina	045804	⤷ Start Trial
Argentina	077396	⤷ Start Trial
Austria	E435029	⤷ Start Trial
Australia	2004277934	⤷ Start Trial
Belgium	2015C072	⤷ Start Trial
>Country	>Patent Number	>Estimated Expiration

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