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Last Updated: March 28, 2024

Claims for Patent: 7,422,739


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Summary for Patent: 7,422,739
Title:Anti-CD20 antibodies
Abstract: Disclosed are chimeric, immunologically active, isolated, and radiolabeled antibodies directed against the CD20 antigen. The antibodies are useful for treating and diagnosing B cell disorders.
Inventor(s): Anderson; Darrell R. (Escondido, CA), Hanna; Nabil (Rancho Santa Fe, CA), Newman; Roland A. (San Diego, CA), Reff; Mitchell E. (San Diego, CA), Rastetter; William H. (Rancho Santa Fe, CA)
Assignee: Biogen Idec Inc. (Cambridge, MA)
Application Number:09/911,703
Patent Claims:1. An immunologically active chimeric anti-CD20 antibody, wherein the antibody comprises a light chain variable region comprising the amino acid sequence shown as residues 23 to 128 of SEQ ID NO: 4 and a heavy chain variable region comprising the amino acid sequence shown as residues 20 to 140 of SEQ ID NO: 6.

2. The chimeric anti-CD20 antibody of claim 1 which is an IgG1.

3. A composition comprising a chimeric anti-CD20 antibody according to claim 1 and a pharmaceutically acceptable buffer.

4. The composition of claim 3 which is suitable for parenteral administration.

5. The composition of claim 4 wherein the parenteral administration is selected from the group consisting of intravenous, intramuscular, vaginal, intraperitoneal, and subcutaneous administration.

6. The composition of claim 3 which is formulated to deliver an effective dose ranging from about 0.01 to 30 mg/kg body weight upon administration to a patient.

7. The composition of claim 6 wherein the dose ranges from about 0.01 to about 25 mg/kg body weight.

8. The composition of claim 6 wherein the dose ranges from about 0.4 mg to about 20 mg/kg body weight.

9. An isolated anti-CD20 antibody, wherein the antibody comprises a light chain variable region comprising the amino acid sequence shown as residues 23 to 128 of SEQ ID NO: 4 and a heavy chain variable region comprising the amino acid sequence shown as residues 20 to 140 of SEQ ID NO: 6.

10. The anti-CD20 antibody of claim 9 wherein the antibody is murine.

11. A composition comprising an anti-CD20 antibody according to claim 9 and a pharmaceutically acceptable buffer.

12. The chimeric antibody of claim 1 wherein the antibody is not conjugated to a toxin or radioisotope.

13. The chimeric antibody of claim 1 wherein the antibody comprises a human light chain kappa constant region and a human heavy chain gamma 1 constant region.

International Patent Family for US Patent 7,422,739

Country Patent Number Estimated Expiration
South Africa 938466 ⤷  Try a Trial
World Intellectual Property Organization (WIPO) 9411026 ⤷  Try a Trial
United States of America 7744877 ⤷  Try a Trial
United States of America 7381560 ⤷  Try a Trial
United States of America 6682734 ⤷  Try a Trial
United States of America 6399061 ⤷  Try a Trial
>Country >Patent Number >Estimated Expiration

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