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Last Updated: March 28, 2024

Claims for Patent: 7,374,758


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Summary for Patent: 7,374,758
Title:Modified chimeric polypeptides with improved pharmacokinetic properties and methods of using thereof
Abstract: Modified chimeric polypeptides with improved pharmacokinetics are disclosed. Specifically, modified chimeric Flt1 receptor polypeptides that have been modified in such a way as to improve their pharmacokinetic profile are disclosed. Also disclosed are methods of making and using the modified polypeptides including but not limited to using the modified polypeptides to decrease or inhibit plasma leakage and/or vascular permeability in a mammal.
Inventor(s): Papadopoulos; Nicholas J. (Lagrangeville, NY), Davis; Samuel (New York, NY), Yancopoulos; George D. (Yorktown Heights, NY)
Assignee: Regeneron Pharmaceuticals, Inc. (Tarrytown, NY)
Application Number:11/016,503
Patent Claims:1. A method of inhibiting vascular endothelial growth factor (VEGF) activity in a mammal, comprising: administering a pharmaceutical composition to the mammal, wherein the pharmaceutical composition comprises (a) a VEGF antagonist, and (b) a pharmaceutically acceptable carrier wherein the VEGF antagonist comprises a dimeric fusion polypeptide comprising two fusion polypeptides, each fusion polypeptide comprising: (i) a VEGF receptor component consisting of an immunoglobulin-like (Ig) domain 2 of a first VEGF receptor human Flt1 and Ig domain 3 of a second VEGF receptor human Flk1 or human Flt4; and (ii) a multimerizing component, wherein VEGF activity is inhibited.

2. The method of claim 1, wherein the mammal is a human.

3. A method of inhibiting tumor growth in a mammal, comprising: administering a pharmaceutical composition to the mammal, wherein the pharmaceutical composition comprises (a) a VEGF antagonist, and (b) a pharmaceutically acceptable carrier wherein the VEGF antagonist comprises a dimeric fusion polypeptide comprising two fusion polypeptides, each fusion polypeptide comprising: (i) a VEGF receptor component consisting of an immunoglobulin-like (Ig) domain 2 of a first VEGF receptor human Flt1 and Ig domain 3 of a second VEGF receptor human Flk1 or human Flt4; and (ii) a multimerizing component, wherein tumor growth is inhibited.

International Patent Family for US Patent 7,374,758

Country Patent Number Estimated Expiration
South Africa 200600157 ⤷  Try a Trial
South Africa 200110068 ⤷  Try a Trial
Yugoslavia 86901 ⤷  Try a Trial
World Intellectual Property Organization (WIPO) 2005000895 ⤷  Try a Trial
World Intellectual Property Organization (WIPO) 02060489 ⤷  Try a Trial
World Intellectual Property Organization (WIPO) 0075319 ⤷  Try a Trial
Uruguay 28396 ⤷  Try a Trial
>Country >Patent Number >Estimated Expiration

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