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Last Updated: May 8, 2024

Claims for Patent: 7,374,757

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Summary for Patent: 7,374,757

Title:	Modified chimeric polypeptides with improved pharmacokinetic properties
Abstract:	Modified chimeric polypeptides with improved pharmacokinetics are disclosed. Specifically, modified chimeric Flt1 receptor polypeptides that have been modified in such a way as to improve their pharmacokinetic profile are disclosed. Also disclosed are methods of making and using the modified polypeptides including but not limited to using the modified polypeptides to decrease or inhibit plasma leakage and/or vascular permeability in a mammal.
Inventor(s):	Papadopoulos; Nicholas J. (Lagrangeville, NY), Davis; Samuel (New York, NY), Yancopoulos; George D. (Yorktown Heights, NY)
Assignee:	Regeneron Pharmaceuticals, Inc. (Tarrytown, NY)
Application Number:	11/016,097
Patent Claims:	1. A fusion protein, consisting of (a) a vascular endothelial growth factor (VEGF) receptor component having immunoglobulin-like (Ig) domains consisting of an Ig domain 2 of a first VEGF receptor human Flt1 and Ig domain 3 of a second VEGF receptor human Flk1; and (b) a multimerizing component, wherein the fusion protein binds VEGF. 2. The fusion protein of claim 1, wherein the first VEGF receptor component is upstream of the second VEGF receptor component. 3. The fusion protein of claim 1, wherein the first VEGF receptor component is downstream of the second VEGF receptor component. 4. The fusion protein of claim 1, wherein the multimerizing component comprises an immunoglobulin domain. 5. The fusion protein of claim 4, wherein the immunoglobulin domain is selected from the group consisting of the Fc domain of IgG, and the heavy chain of IgG. 6. A fusion protein encoded by a nucleic acid sequence selected from: (a) SEQ ID NO:15; and (b) nucleic acid sequences which, as a result of the degeneracy of the genetic code, differ from the nucleic acid sequence of SEQ ID NO:15. 7. A fusion protein consisting of immunoglobulin-like (Ig) domain 2 of a first vascular endothelial growth factor (VEGF) receptor upstream of Ig domain 3 of a second VEGF receptor and a multimerizing component, wherein the fusion protein comprises the amino acid sequence SEQ ID NO:16.

Details for Patent 7,374,757

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Regeneron Pharmaceuticals, Inc.	EYLEA	aflibercept	Injection	125387	11/18/2011	⤷ Try a Trial	2019-06-08
Regeneron Pharmaceuticals, Inc.	EYLEA	aflibercept	Injection	125387	08/16/2018	⤷ Try a Trial	2019-06-08
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 7,374,757

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Country	Patent Number	Estimated Expiration
South Africa	200600157	⤷ Try a Trial
South Africa	200110068	⤷ Try a Trial
Yugoslavia	86901	⤷ Try a Trial
World Intellectual Property Organization (WIPO)	2005000895	⤷ Try a Trial
World Intellectual Property Organization (WIPO)	02060489	⤷ Try a Trial
World Intellectual Property Organization (WIPO)	0075319	⤷ Try a Trial
Uruguay	28396	⤷ Try a Trial
>Country	>Patent Number	>Estimated Expiration

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