Claims for Patent: 7,374,551

Summary for Patent: 7,374,551

Title:	Minimally invasive fat cavitation method
Abstract:	A method of fat cavitation including infiltrating adipose tissue with a liquid, creating a puncture in a patient\'s skin, providing a wire, the wire being generally uniform in diameter and having a first end and a second end and introducing the second end of the wire through the puncture in the patient\'s skin. The method further includes placing at least a portion of the second end of the wire in contact the adipose tissue, generating an ultrasonic wave, transmitting the ultrasonic wave to the second end of the wire, creating cavitation bubbles in at least a portion of the targeted adipose tissue and liquefying at least a portion of the targeted adipose tissue. It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.
Inventor(s):	Liang; Marc D. (Pittsburgh, PA), Narayanan; Krishna (Pittsburgh, PA)
Assignee:	Pittsburgh Plastic Surgery Research Associates (Pittsburgh, PA)
Application Number:	10/370,214
Patent Claims:	1. A method of fat cavitation, comprising: infiltrating subcutaneous adipose tissue with a liquid comprising microbubbles up to about 400 ml and at least one of normal saline, lactated Ringer's solution and Krebs solution; creating a puncture in the patient's skin; providing a wire, the wire being generally uniform in diameter and having a first end and a second end; introducing the second end of the wire through the puncture in the patient's skin; placing at least a portion of the second end of the wire in contact with the subcutaneous adipose tissue; generating an ultrasonic wave; transmitting the ultrasonic wave to the second end of the wire; creating cavitation bubbles in at least a portion of the targeted adipose tissue; and liquefying at least a portion of the targeted adipose tissue up to a combined liquefied adipose tissue and infiltrated liquid of about 500 ml. 2. The method of claim 1 further comprising monitoring the location of the wire. 3. The method of claim 2 wherein the monitoring comprises feeling the wire manually. 4. The method of claim 2 wherein the monitoring comprises using diagnostic ultrasound equipment. 5. The method of claim 1 wherein the liquid comprises a clysis solution comprising Kregs-Ringer bicarbonate solution. 6. The method of claim 5 wherein the clysis solution further comprises collagenase. 7. The method of claim 5 wherein the clysis solution further comprises lipase. 8. The method of claim 1 wherein the infiltrated liquid further comprises an anesthetic preparation. 9. The method of claim 8 wherein the anesthetic preparation comprises lidocaine. 10. The method of claim 9 wherein the anesthetic preparation further comprises epinepbrine. 11. The method of claim 1 comprising: removing the wire from the patient; introducing a microsuction cannula through the puncture in the patient's skin; placing the microsuction cannula in proximity to the liquefied adipose tissue; applying suction to the microsuction cannula; and aspirating the liquefied adipose tissue through the microsuction cannula. 12. The method of claim 1 further comprising marking the skin of the patient to identify the area of treatment prior to infiltrating the adipose tissue with the liquid. 13. The method of claim 1 wherein the wire is 0.5 to 1.5 mm in diameter. 14. The method of claim 13 wherein the wire is 1.0 to 1.5 mm in diameter. 15. The method of claim 13 wherein the wire 1.2 to 1.5 mm in diameter. 16. A kit for carrying out a method of subcutaneous fat cavitation, comprising: a surgical cutting instrument sized for making an incision of about 2 mm or less; a clysis solution comprised of microbubbles and at least one of normal saline, lactated Ringer's solution, Krebs solution and Krebs-Ringer bicarbonate solution; and an ultrasound device, comprising a catheter; a wire disposed within said catheter, said wire having a generally uniform diameter of about 0.5 to 1.5 mm and having a first end and a second end; a horn in communication with said wire; and a generator in communication with said horn. 17. The kit of claim 16 wherein said surgical cutting instrument comprises a No. 11 blade knife. 18. The kit of claim 16 wherein said surgical cutting instrument comprises a needle. 19. The kit of claim 17 wherein the clysis solution further comprises an anesthetic preparation. 20. The kit of claim 19 wherein the clysis solution further comprises lidocaine. 21. The kit of claim 20 wherein said anesthetic preparation further comprises epinephrine. 22. The kit of claim 16 wherein said clysis solution comprises collagenase. 23. The kit of claim 16 wherein said clysis solution comprises lipase.

Details for Patent 7,374,551

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965		2039-03-29