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Last Updated: December 16, 2025

Claims for Patent: 7,183,254

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Summary for Patent: 7,183,254

Title:	Use of leptin for treating human lipoatrophy and method of determining predisposition to said treatment
Abstract:	Leptin, leptin analogs, and leptin derivatives are used to treat patients with lipoatrophy. Leptin is effective against conditions of lipoatrophy for both genetic and acquired forms of the disease. A therapeutically effective amount of leptin can be administered in a variety of ways, including subcutaneously and using gene therapy methods. Methods of the present invention contemplate administration of leptin, leptin analogs, and leptin derivatives to patients having a leptin level of approximately 4 ng/ml or less before treatment.
Inventor(s):	Alexander M. DePaoli, Simeon I. Taylor, Elif A. Oral, Abhimanyu Garg
Assignee:	Amgen Inc , University of Texas System , US Department of Health and Human Services
Application Number:	US10/623,189

Details for Patent 7,183,254

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Chiesi Farmaceutici S.p.a.	MYALEPT	metreleptin	For Injection	125390	February 24, 2014	7,183,254	2023-07-18
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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