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Last Updated: March 29, 2024

Claims for Patent: 6,875,606


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Summary for Patent: 6,875,606
Title: Human .alpha.-7 nicotinic receptor promoter
Abstract:The present invention is directed to methods and compositions related to .alpha.7 acetylcholine nicotinic receptor genes, in particular, the human .alpha.7 nicotinic acetylcholine receptor gene. This .alpha.7 acetylcholine nicotinic receptor gene is associated with the pathophysiological aspects of the disease schizophrenia. The present invention further provides methods and compositions to screen populations for abnormal .alpha.7, as well as methods and compositions for development of therapeutics.
Inventor(s): Leonard; Sherry (Denver, CO), Freedman; Robert (Englewood, CO)
Assignee: The United States of America as represented by the Department of Veterans Affairs (Washington, DC)
Application Number:08/956,518
Patent Claims:1. An isolated nucleotide sequence consisting of a portion of the human alpha-7 neuronal nicotinic receptor, set forth as nucleotides 1-392 of SEQ ID NO:94.

2. A vector comprising the nucleotide sequence of claim 1.

3. An isolated host cell transformed with the vector of claim 2.

4. The host cell of claim 3, wherein said cell is selected from the group consisting of a bacterial cell, a yeast cell, an amphibian cell and a mammalian cell.

5. An isolated nucleotide sequence consisting of a 5' portion of the human alpha-7 neuronal nicotinic receptor and exon 1, as set forth as nucleotides 1-447 of SEQ ID NO:94.

6. An isolated nucleotide sequence consisting of a 5' portion of the human alpha-7 neuronal nicotinic receptor, exon 1, and the intron 1 slice donor, as set forth as nucleotides 1-457 of SEQ ID NO:94.

Details for Patent 6,875,606

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 06/04/1986 ⤷  Try a Trial 2039-03-29
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 ⤷  Try a Trial 2039-03-29
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b Injection 103132 ⤷  Try a Trial 2039-03-29
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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