Last Updated: August 9, 2026

Claims for Patent: 6,716,602

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Summary for Patent: 6,716,602

Title:	Metabolic rate shifts in fermentations expressing recombinant proteins
Abstract:	The invention provides a method for increasing product yield of a polypeptide of interest produced by recombinant host cells, where expression of the polypeptide by the recombinant host cells is regulated by an inducible system. More specifically, the method involves culturing the recombinant host cells under conditions of high metabolic and growth rate and then reducing the metabolic rate of the recombinant host cells at the time of induction of polypeptide expression. In particular, the invention provides a method of increasing product yield of an antibody, growth factor, or protease produced by a recombinant E. coli host cell regulated by an inducible system.
Inventor(s):	Dana Andersen, John Joly, Bradley R. Snedecor
Assignee:	Genentech Inc
Application Number:	US10/000,655

Details for Patent 6,716,602

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Genentech, Inc.	LUCENTIS	ranibizumab	Injection	125156	June 30, 2006	⤷ Start Trial	2021-11-01
Genentech, Inc.	LUCENTIS	ranibizumab	Injection	125156	August 10, 2012	⤷ Start Trial	2021-11-01
Genentech, Inc.	LUCENTIS	ranibizumab	Injection	125156	October 13, 2016	⤷ Start Trial	2021-11-01
Genentech, Inc.	LUCENTIS	ranibizumab	Injection	125156	March 20, 2018	⤷ Start Trial	2021-11-01
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 6,716,602

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Country	Patent Number	Estimated Expiration
World Intellectual Property Organization (WIPO)	0240697	⤷ Start Trial
United States of America	2002164700	⤷ Start Trial
Portugal	1332222	⤷ Start Trial
Japan	4878724	⤷ Start Trial
Japan	2004517614	⤷ Start Trial
Israel	155482	⤷ Start Trial
>Country	>Patent Number	>Estimated Expiration

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