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Last Updated: December 31, 2025

Claims for Patent: 6,709,655

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Summary for Patent: 6,709,655

Title:	Pharmaceutical composition of F(ab1)2 antibody fragments and a process for the preparation thereof
Abstract:	The present invention is directed to a pharmaceutical composition comprising F(ab′)2 antibody fragments that are preferably free from albumin and of whole antibodies and also substantially free of pyrogens, and an effective amount of a pharmaceutically acceptable carrier. It is also directed to a method for the production of a pharmaceutical composition comprising F(ab′)2 antibody fragments using serum or blood plasma of a mammal that has been previously immunized, as a source of antibodies. The serum or blood plasma is digested with pepsin, followed by separation and purification until the pharmaceutical composition of F(ab′)2 fragments is free of albumin and complete antibodies, and substantially free of pyrogens.
Inventor(s):	Juan López de Silanes, Rita Mancilla Nava, Jorge F. Paniagua Solis
Assignee:	Instituto Bioclon de C V SA
Application Number:	US09/798,076
Patent Claims:

Details for Patent 6,709,655

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Llc		antivenin (latrodectus mactans)	For Injection	101062	February 13, 1936	6,709,655	2021-02-28
Rare Disease Therapeutics, Inc. (rdt)	ANASCORP	centruroides (scorpion) immune f(ab')2 (equine) injection	For Injection	125335	August 03, 2011	6,709,655	2021-02-28
Rare Disease Therapeutics, Inc. (rdt)	ANAVIP	crotalidae immune f(ab')2 (equine)	For Injection	125488	May 06, 2015	6,709,655	2021-02-28
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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