Last Updated: May 20, 2026

Claims for Patent: 6,656,461

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Summary for Patent: 6,656,461

Title:	Therapeutic treatment of chronic obstructive pulmonary disease
Abstract:	The present invention provides a method of treating or preventing a chronic obstructive pulmonary disease in a subject, comprising administering to said subject an amount of an agent effective to inhibit apoptosis of the subject's lung cells and thus treat or prevent chronic obstructive pulmonary disease in the subject. The present invention provides for a method of identifying a compound effective to treat or prevent a chronic obstructive pulmonary disease, comprising (a) contacting lung cells from a subject having a chronic obstructive pulmonary disease with the compound and measuring the level of apoptosis of the lung cells in the presence of said compound, (b) measuring the level of apoptosis of the lung cells from the same subject in the absence of said compound, (c) comparing the level of apoptosis in step (a) with the level of apoptosis in step (b), wherein a higher level of apoptosis in step (a) indicate that the compound is effective to treat or prevent chronic obstructive pulmonary disease.
Inventor(s):	Jeanine D'Armiento, Kazushi Imai
Assignee:	Columbia University in the City of New York
Application Number:	US09/514,885

Details for Patent 6,656,461

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Baxter Healthcare Corporation	ARTISS	fibrin sealant (human)	Solution	125266	March 19, 2008	⤷ Start Trial	2020-02-29
Baxter Healthcare Corporation	ARTISS	fibrin sealant (human)	For Solution	125266	March 19, 2008	⤷ Start Trial	2020-02-29
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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