Last Updated: May 11, 2026

Claims for Patent: 6,583,272

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Summary for Patent: 6,583,272

Title:	Erythropoietin conjugates
Abstract:	Conjugates of erythropoietin with poly(ethylene glycol) comprise an erythropoietin glycoprotein having at least one free amino group and having the in vivo biological activity of causing bone marrow cells to increase production of reticulocytes and red blood cells and selected from the group consisting of human erythropoietin and analogs thereof which have sequence of human erythropoietin modified by the addition of from 1 to 6 glycosylation sites or a rearrangement of at least one glycosylation site; the glycoprotein being covalently linked to "n" poly(ethylene glycol) groups of the formula -CO-(CH2)x(OCH2CH2)m-OR with the carbonyl of each poly(ethylene glycol) group forming an amide bond with one of said amino groups; wherein R is lower alkyl; x is 2 or 3; m is about 450 to about 900; n is from 1 to 3; and n and m are chosen so that the molecular weight of the conjugate minus the erythropoietin glycoprotein is from 20 kilodaltons to 100 kilodaltons.
Inventor(s):	Pascal Sebastian Bailon
Assignee:	Hoffmann La Roche Inc
Application Number:	US09/604,938

Details for Patent 6,583,272

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Vifor (international) Inc.	MIRCERA	methoxy polyethylene glycol-epoetin beta	Injection	125164	April 28, 2016	6,583,272	2020-06-27
Vifor (international) Inc.	MIRCERA	methoxy polyethylene glycol-epoetin beta	Injection	125164	November 14, 2007	6,583,272	2020-06-27
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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