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Last Updated: March 19, 2024

Claims for Patent: 6,555,064


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Summary for Patent: 6,555,064
Title: Method for determining platelet inhibitor response
Abstract:An apparatus is provided for performing an activated clotting time test on a sample of blood containing platelets using a plunger sensor technique, the apparatus comprising a test cell, and wherein the test cell comprises an anticoagulant, a contact activator, and a predetermined amount of a platelet inactivating agent.
Inventor(s): Baugh; Robert F. (Parker, CO), Lane; Carole G. (Greenwood Village, CO), Wilson; Adrian C. (Denver, CO)
Assignee: Medtronic, Inc. (Minneapolis, MN)
Application Number:09/811,216
Patent Claims:1. An apparatus for performing an activated clotting time test on a sample of blood containing platelets, said apparatus comprising a test cell, and wherein said test cell comprises an anticoagulant, a contact activator, and a predetermined amount of a platelet inactivating agent.

2. The apparatus of claim 1, wherein the anticoagulant is heparin.

3. The apparatus of claim 2, wherein the amount of heparin in said cell is between about 1 unit and about 4 units per milliliter of blood sample.

4. The apparatus of claim 1, wherein the contact activator is a particle having a negatively charged surface.

5. The apparatus of claim 3, wherein said particle is kaolin.

6. The apparatus of claim 4, wherein the amount of contact activator in said cell is between about 2 percent and about 15 percent.

7. The apparatus of claim 4, wherein said particle is diatomaceous earth.

8. The apparatus of claim 4, wherein said particle is powdered glass.

9. The apparatus of claim 4, wherein said particle is silica.

10. The apparatus of claim 1, wherein said platelet inactivating agent is selected from the group consisting of Abciximab, 4-[4-[4-(aminoiminomethyl)phenyl]-1-piperazinyl]-1-piperidineacetic acid, hydrochloride trihydrate, and acetylsalicylic acid.

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