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Last Updated: December 17, 2025

Claims for Patent: 6,406,705

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Summary for Patent: 6,406,705

Title:	Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
Abstract:	The present invention relates generally to adjuvants, and in particular to methods and products utilizing a synergistic combination of immunostimulatory oligonucleotides having at least one unmethylated CpG dinucleotide (CpG ODN) and a non-nucleic acid adjuvant. Such combinations of adjuvants may be used with an antigen or alone. The present invention also relates to methods and products utilizing immunostimulatory oligonucleotides having at least one unmethylated CpG dinucleotide (CpG ODN) for induction of cellular immunity in infants.
Inventor(s):	Heather L. Davis, Joachim Schorr, Arthur M. Krieg
Assignee:	Ottawa Health Research Institute , Coley Pharmaceutical GmbH , University of Iowa Research Foundation UIRF
Application Number:	US09/325,193

Details for Patent 6,406,705

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Emergent Product Development Gaithersburg, Inc.	CYFENDUS	anthrax vaccine adsorbed, adjuvanted	Injection	125761	July 20, 2023	6,406,705	2019-06-03
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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