Last Updated: April 23, 2026

Claims for Patent: 6,368,811

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Summary for Patent: 6,368,811

Title:	Syndecan interacting proteins and the use thereof
Abstract:	The invention relates to the identification of a new protein that binds to the cytoplasmic domain of syndecan. This new protein, denominated as “syntenin”, contains 298 amino acids and is characterized by a tandem repeat of PDZ-domains that reacts with the C-terminal amino acid sequence of syndecans. The amino-terminal region of syntenin further comprises five tyrosine residues whereas no tyrosine residues are present in the remaining part of the protein. The present invention further discloses a nucleic acid encoding syntenin, a method to screen for components interfering with the syndecan-syntenin interaction, a method for diagnosing Alzheimer's disease, inflammatory diseases, and malignancies and a pharmaceutical composition for healing the latter diseases.
Inventor(s):	Jan Grootjans, Pascale Zimmermann, Guido David
Assignee:	Vlaams Instituut voor Biotechnologie VIB
Application Number:	US09/427,261

Details for Patent 6,368,811

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Wyeth Pharmaceuticals Llc	XYNTHA, XYNTHA SOLOFUSE	antihemophilic factor (recombinant), plasma/albumin free	For Injection	125264	February 21, 2008	⤷ Start Trial	2019-10-25
Wyeth Pharmaceuticals Llc	XYNTHA, XYNTHA SOLOFUSE	antihemophilic factor (recombinant), plasma/albumin free	For Injection	125264	August 06, 2010	⤷ Start Trial	2019-10-25
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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