Last Updated: May 14, 2026

Claims for Patent: 6,331,304

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Summary for Patent: 6,331,304

Title:	Macrophage-infecting parasites expressing a granulocyte macrophage colony stimulating factor
Abstract:	Strains of Leishmanda and other macrophage-infecting parasites are provided which express the GM-CSF gene which are useful in treating hosts infected by the parasite and in protecting hosts against disease caused by infection of hosts by parasites. The parasites are reduced in their ability to infect or survive in macrophages and hence are attenuated. At least one gene of the parasite contributing to the virulence thereto may be functionally disabled. The attenuated strains may be used for administration to a host (a) to treat a host infected by Leishmania or (b) to confer protection against disease caused by a virulent Leishmania strain, or as a diagnostic reagent.
Inventor(s):	Barbara Papadopoulou, Marc Ouellette, Martin Olivier
Assignee:	Universite Laval
Application Number:	US08/713,768

Details for Patent 6,331,304

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
California Department Of Public Health (cdph)	BABYBIG	botulism immune globulin intravenous (human)	For Injection	125034	October 23, 2003	6,331,304	2016-09-13
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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