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Last Updated: April 28, 2024

Claims for Patent: 6,270,757

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Summary for Patent: 6,270,757

Title:	Formulations for IL-11
Abstract:	The present invention provides novel formulations comprising IL-11 and glycine. Also provided are compositions, both liquid and lyophilized, comprising IL-11 and glycine and optionally, a buffering agent such as histidine and phosphate.
Inventor(s):	Warne; Nicholas W. (Methuen, MA)
Assignee:	Genetics Institute, Inc. (Cambridge, MA)
Application Number:	08/230,982
Patent Claims:	1. A composition comprising IL-11 and glycine. 2. The composition of claim 1, where the amount of said glycine ranges from 50 to 600 mM. 3. The composition of claim 1, where the amount of said glycine is about 300 mM. 4. The composition of claim 1, where the amount of said glycine is about 150 mM. 5. The composition of claim 1, where the amount of said IL-11 is about 0.1 to 20 mg/mL. 6. The composition of claim 1, where the amount of said IL-11 is about 5.0 mg/mL. 7. The composition of claim 1, where the amount of said IL-11 is about 5.0 mg/mL and said glycine is about 300 mM. 8. A composition comprising IL-11, glycine, and a buffering agent. 9. The composition of claim 8, where said buffering agent is a member selected from the group consisting of histidine and phosphate. 10. The composition of claim 9, where said buffering agent is sodium phosphate. 11. The composition of claim 9, where the amount of said phosphate ranges from about 5 mM to 20 mM. 12. The composition of claim 10, where the amount of said phosphate is about 10 mM. 13. The composition of claim 9, where the amount of said histidine ranges from about 5 mM to 40 mM. 14. The composition of claim 11, where the amount of said histidine is about 20 mM. 15. A composition comprising about 5.0 mg/mL IL-11, 300 mM glycine, and 10 mM sodium phosphate. 16. A composition comprising about 5.0 mg/mL IL-11, 300 mM glycine, and 20 mM histidine. 17. A composition comprising des-Pro-IL-11 and glycine. 18. The composition of claim 17 where the amount of said des-Pro-IL-11 is about 0.1 to 20 mg/mL. 19. The composition of claim 17 where the amount of said glycine is about 50 to 600 mM. 20. A composition comprising about 5.0 mg/mL des-Pro-IL-11 and 300 mM glycine.

Details for Patent 6,270,757

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Wyeth Pharmaceuticals Inc.	NEUMEGA	oprelvekin	For Injection	103694	11/25/1997	⤷ Try a Trial	2039-03-29
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 6,270,757

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Country	Patent Number	Estimated Expiration
Austria	210995	⤷ Try a Trial
Australia	1934495	⤷ Try a Trial
Australia	684620	⤷ Try a Trial
>Country	>Patent Number	>Estimated Expiration

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