Make Better Decisions - Finding and Evaluating Generic and Branded Drug Market Entry Opportunities

Get the Book: Make Better Decisions

Finding and Evaluating Generic and Branded Drug Market Entry Opportunities

PDF eBook: Just $10 Get Print Book on Amazon

Serving leading biopharmaceutical companies globally:

McKesson
AstraZeneca
Mallinckrodt
Boehringer Ingelheim
Dow
Colorcon

Last Updated: October 19, 2019

DrugPatentWatch Database Preview

Claims for Patent: 6,239,144

See Plans and Pricing

« Back to Dashboard

Summary for Patent: 6,239,144
Title: Methods of treating bone loss
Abstract:The present invention provides methods of treating or preventing conditions associated with a lack of parathyroid hormone comprising administering to a mammal in need thereof an effective amount of a compound having activity as a tachykinin receptor antagonist. In a most preferred embodiment the present invention provides methods of increasing bone growth in a mammal which comprises administering to a mammal in need thereof an effective amount of a compound having activity as a tachykinin receptor antagonist. Another embodiment of this invention provides methods of treating hyperparathyroidism in a mammal comprising administering to a mammal in need thereof an effective amount of a compound having activity as a tachykinin receptor antagonist.
Inventor(s): Galvin; Rachelle J (Indianapolis, IN), Gitter; Bruce D (Carmel, IN)
Assignee: Eli Lilly and Company (Indianapolis, IN)
Application Number:09/319,388
Patent Claims:1. A method for the treatment of a condition associated with a deficiency of parathyroid hormone in a mammal which comprises administering to a mammal in need thereof an effective amount of a compound or composition having activity as a tachykinin receptor antagonist.

2. A method as claimed in claim 1 wherein the compound having activity as a tachykinin receptor antagonist is (R)-2-[N-(2-((4-cycdohexyl)piperazin-1-yl)acetyl)amino]-3-(1H-indol-3-yl)- 1-[N-(2-methoxybenzyl)acetylamino]propane, (R)-3-(1H-indol-3-yl)-1-[N-(2-methoxybenzyl)acetylamino]-2-[N-(2-(4-piperi din-1-yl)piperidin-1-yl)acetyl)amino]propane, (R)-3-(1H-indol-3-yl)-1-[N-(2-methoxybenzyl)acetylamio]-2-[N-(2-(4-(piperi din-1-yl)piperidin-1-yl)acetyl)amino]propane dihydrohloride trihydrate, 1-(2-bromobenzyl)-2-(3,5-dimethylphenyl)-6-[2-(N,N-dinethylamino)ethoxy]be nzidazole, RP 67580, (.+-.)CP 96345, 5-(3,5-bistrifuoromethylphenyl)-1-(3-indolyl)-2-((4-methylpiperazin-1-yl)a cetamido)-3-pentanone, (4-methylphenyl)methyl [R-(R*,S*)]-[1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-[(1-phenylethyl)amin o]ethyl]carbamate, (S)-1-(2-methoxybenzyl)-2-[(4-phenyl-1-piperazinyl)methyl]-4-(1H-indol-3-y lmethyl)-2-imidazoline, or 1-(3,5-dimethylbenzyloxy)-2-anmino-2-phenylcydohexane, or a pharmaceutically acceptable salt or solvate thereof.

3. A method as claimed in claim 2 employing (R)-3-(1H-indol-3-yl)-1-[N-(2-methoxybenzyl)acetylamino]-2-[N-(2-(4-(piper idin-1-yl)piperidin-1-yl)acetyl)amino]propane dihydrodhloride trihydrate.

4. A method for enhancing bone growth in a mammal which comprises administering to a mammal in need thereof an effective amount of a compound or composition having activity as a tachykinin receptor antagonist.

5. A method as cained in claim 4 wherein the compound having activity as a tachykinin receptor antagonist is (R)-2-[N-(2-((4-cydohexyl)piperazin-1-yl)acetyl)amino]-3-(1H-indol-3-yl)-1 -[N-(2-methoxybenzyl)acetylamino]propane, (R)-3-(1H-indol-3-yl)-1-[N-(2-methoxybenzyl)acetylamino]-2-[N-(2-(4-(piper idin-1-yl)piperidin-1-yl)acetyl)amino]propane, (R)-3-(1H-indol-3-yl)-1-[N-(2-methoxybenzyl)acetylamino]-2-[N-(2-(4-piperi din-1-yl)piperidin-1-yl)acetyl)amino]propane dihydrocloride trihydrate, 1-(2-bromobenzyl)-2-(3,5-dimethylphenyl)-6-[2-(N,N-dimethylamino)ethoxy]be nzimidazole, RP 67580, (.+-.)CP 96345, 5-(3,5-bistifiuoromethylphenyl)-1-(3-indolyl)-2-((4-methylpiperazin-1-yl)a cetamido)-3-pentanone, (4-methylphenyl)methyl [R-(R*,S*)]-[1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-[(1-phenylethyl)amin o]ethyl]carbamate, (S)-1-(2-methoxybenzyl)-2-[(4-phenyl-1-piperazinyl)methyl]-4-(1H-indol-3-y lmethyl)-2-imidazoline, or 1-(3,5-dimethylbenzyloxy)-2-amino-2-phenylcyclohexane, or a pharmaceutically acceptable salt or solvate thereof.

6. A method as daimed in claim 5 employing (R)-3-(1H-indol-3-yl)-1-[N-(2-methoxybenzyl)acetylamio]-2-[N-(2-(4(piperid in-1-yl)piperidin-1-yl)acetyl)amino]propane dihydrochloride trihydrate.

7. A method for treating hyperparathyroidism in a mammal which comprises administering to a mammal in need thereof an effective amount of a compound or composition having activity as a tachykinin receptor antagonist.

8. A method as daimed in claim 7 wherein the compound having activity as a tachykinin receptor antagonist is (R)-2-[N-(2-((4-cydohexyl)piperazin-1-yl)acetyl)amino]-3-(1H-indol-3-yl)-1 -[N-(2-methoxybenzyl)acetylamino]propane, (R)-3-(1H-indol-3-yl)-1-[N-(2-methoxybenzyl)acetylamino]-2-[N-(2-(4-piperi din-1-yl)piperidin-1-yl)acetyl)amino]propane, (R)-3-(1H-indol-3-yl)-1-[N-(2-methoxybenzyl)acetylamino]-2-[N-(2-(4-piperi din-1-yl)piperidin-1-yl)acetyl)amino]propane dihydrochloride trihydrate, 1-(2-bromobenzyl)-2-(3,5-dimethylphenyl)-6-[2-(N,N-dimethylamino)ethoxy]be nzimidazole, RP 67580, (.+-.)CP 96345, 5-(3,5-bistrifluoromethylphenyl)-1-(3-indolyl)-2-((4-methylpiperazin-1-yl) acetamido)-3-pentanone, (4-methylphenyl)methyl [R-(R*,S*)]-[1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-[(1-phenylethyl)amin o]ethyl]carbamate, (S)-1-(2-methoxybenzyl)-2-[(4-phenyl-1-piperazinyl)methyl]-4-(1H-indol-3-y lmethyl)-2-imidazoline, or 1-(3,5-dimethylbenzyloxy)-2-amino-2-phenylcyclohexane, or a pharmaceutically acceptable salt or solvate thereof.

9. A method as daimed in claim 8 employing (R)-3-(1H-indol-3-yl)-1-[N-(2-methoxybenzyl)acetylamino]-2-[N-(2-(4-(piper idin-1-yl)piperidin-1-yl)acetyl)amino]propane dihydrochloride trihydrate.

10. A method for inducing the secretion of parathyroid hormone in a mammal which comprises administering to a mammal in need thereof an effective amount of a compound or composition having activity as a tachykinin receptor antagonist.

Summary for Patent:   Start Trial

PCT Information
PCT FiledApril 03, 1998PCT Application Number:PCT/US98/06674
PCT Publication Date:October 08, 1998PCT Publication Number:WO98/43639

Details for Patent 6,239,144

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 001 2015-01-23   Start Trial Eli Lilly and Company (Indianapolis, IN) 2017-04-03 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23   Start Trial Eli Lilly and Company (Indianapolis, IN) 2017-04-03 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 003 2015-01-23   Start Trial Eli Lilly and Company (Indianapolis, IN) 2017-04-03 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 004 2015-01-23   Start Trial Eli Lilly and Company (Indianapolis, IN) 2017-04-03 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

Make Better Decisions: Try a trial or see plans & pricing

Serving leading biopharmaceutical companies globally:

Johnson and Johnson
Colorcon
Boehringer Ingelheim
Merck
Medtronic
Express Scripts

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.