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Last Updated: May 21, 2024

Claims for Patent: 5,980,884


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Summary for Patent: 5,980,884
Title: Methods for retreatment of patients afflicted with Hepatitis C using consensus interferon
Abstract:Methods for the retreatment, using a therapeutically effective amount of interferon consensus, of patients with HCV who exhibit serum ALT values above the upper limit of normal after previous treatment with interferon.
Inventor(s): Blatt; Larry (Boulder, CO), Klein; Michael (Thousand Oaks, CA)
Assignee: Amgen, Inc. (Thousand Oaks, CA)
Application Number:08/595,440
Patent Claims:1. A method for retreating HCV patients, said patients having failed to respond to previous treatment with an interferon, comprising administering to a patient a therapeutically effective amount of interferon consensus.

2. A method according to claim 1, wherein said interferon consensus is selected from the group consisting of IFN-con.sub.1, IFN-con.sub.2, and IFN-con.sub.3.

3. A method according to claim 2, wherein said interferon consensus is IFN-con.sub.1.

4. A method according to claim 1 wherein said interferon consensus is a product of prokaryotic expression of an exogenous DNA sequence.

5. A method according to claim 1, wherein the therapeutically effective amount is administered orally, intravenously, intramuscularly, subcutaneously, intranasally, or intralesionally.

6. A method according to claim 1, wherein the therapeutically effective amount is 15 .mu.g administered subcutaneously three times weekly for 24 weeks.

7. A method for obtaining normalized serum alanine aminotransferase (ALT) levels in a patient suffering from HCV and having failed to respond to previous treatment with interferon therapy, comprising administering to said patient a therapeutically effective amount of interferon consensus.

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