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Last Updated: March 12, 2026

Claims for Patent: 5,962,405


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Summary for Patent: 5,962,405
Title:Storage-stable fibrinogen preparations
Abstract:The invention relates to storage-stable fibrinogen preparations for preparing concentrated fibrinogen solution for use as a tissue adhesive or for preparing fibrinogen solutions for other uses, for example, for infusion purposes. The fibrinogen preparations are characterized in that(i) the lyophilized preparation comprises a substance improving the solubility of fibrinogen such that the reconstitution time is up to 15 minutes, preferably less than 7 minutes, when dissolving with water at room temperature to a solution with a fibrinogen concentration of at least 70 mg/ml and(ii) the ready-to-use tissue adhesive solution obtained from the preparation forms fibrin clots having physiological fibrin structure after mixing with a thrombin-CaCl2 solution.
Inventor(s):Thomas Seelich
Assignee: Baxalta Innovations GmbH , Baxter Healthcare SA
Application Number:US08/838,975

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