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Last Updated: April 27, 2024

Claims for Patent: 5,843,439

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Summary for Patent: 5,843,439

Title:	Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
Abstract:	Disclosed herein are therapeutic treatment protocols designed for the treatment of B cell lymphoma. These protocols are based upon therapeutic strategies which include the use of administration of immunologically active mouse/human chimeric anti-CD20 antibodies, radiolabeled anti-CD20 antibodies, and cooperative strategies comprising the use of chimeric anti-CD20 antibodies and radiolabeled anti-CD20 antibodies.
Inventor(s):	Anderson; Darrell R. (Escondido, CA), Hanna; Nabil (Olivenhain, CA), Leonard; John E. (Encinitas, CA), Newman; Roland A. (San Diego, CA), Reff; Mitchell E. (San Diego, CA), Rastetter; William H. (Rancho Sante Fe, CA)
Assignee:
Application Number:	08/478,967
Patent Claims:	1. A method of treating B-cell lymphoma which includes the following steps: (i) administering, at a first administration period, a radiolabeled anti-CD20 antibody, wherein said antibody is selected from the group consisting of the chimeric anti-CD20 antibody produced by transfectoma TCAE 8, which has been accorded American Type Culture Collection Deposit No. ATCC 69119, and the murine anti-CD20 antibody secreted by a hybridoma identified by American Type Culture Collection Deposit No. HB 11388; and (ii) subsequently administering after step (i) at least one dosage of a chimeric anti-CD20 antibody produced by transfectoma TCAE 8, which has been accorded American Type Culture Collection Deposit No. ATCC 69119. 2. The method of claim 1, wherein multiple dosages of said chimeric anti-CD20 antibodies are administered after said initial administration (i) of said radiolabeled anti-CD20 antibody. 3. The method of claim 1, wherein said radiolabeled antibody administered in step (i) is a radiolabeled murine anti-CD20 antibody, and said murine anti-CD20 antibody is secreted by the hybridoma identified by American Type Culture Collection Deposit No. HB 11388. 4. The method of claim 1, wherein said radiolabeled antibody administered in step (i) is a radiolabeled chimeric anti-CD20 antibody, wherein said chimeric anti-CD20 antibody is produced by transfectoma TCAE 8, which has been accorded American Type Culture Collection Deposit No. ATCC 69119. 5. The method of claim 1, which further includes harvesting of peripheral stem cells (PSC's) or bone marrow (BM) prior to treatment. 6. The method of claim 5, wherein said harvested PSC's or BM is reinfused after treatment. 7. The method of claim 1, wherein the radiolabel contained in said radiolabeled antibody administered in step (i) is selected from the group consisting of iodine (131), indium (131), indium (111), and yttrium (90).

Details for Patent 5,843,439

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Acrotech Biopharma Llc	ZEVALIN	ibritumomab tiuxetan	Injection	125019	02/19/2002	⤷ Try a Trial	2015-12-01
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 5,843,439

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Country	Patent Number	Estimated Expiration
Austria	139900	⤷ Try a Trial
Austria	196606	⤷ Try a Trial
Austria	421335	⤷ Try a Trial
Austria	431158	⤷ Try a Trial
Australia	5603294	⤷ Try a Trial
Australia	688743	⤷ Try a Trial
>Country	>Patent Number	>Estimated Expiration

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