Claims for Patent: 5,762,939

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Summary for Patent: 5,762,939

Title:	Method for producing influenza hemagglutinin multivalent vaccines using baculovirus
Abstract:	A method of preparing a recombinant influenza vaccine using DNA technology is provided. The resulting vaccine is a trivalent influenza vaccine based on a mixture of recombinant hemagglutinin antigens cloned from influenza viruses having epidemic potential. The recombinant hemagglutinin antigens are full length, uncleaved (HA0), glycoproteins produced from baculovirus expression vectors in cultured insect cells and purified under non-denaturing conditions. The process for cloning influenza hemagglutinin genes from influenza A and B viruses uses specially designed oligonucleotide probes and PCR. The cloned HA genes are then modified by deletion of the natural hydrophobic signal peptide sequences and replacing them with a new baculovirus signal peptide. A general approach for the efficient extraction and purification of recombinant HA protein produced in insect cells is also disclosed which can be adapted for the purification of rHA proteins from A sub-types and B type influenza viruses. The procedure produces substantially pure rHA which is a biologically active hemagglutinin, non-denatured, and suitable as a component in human or other animal influenza vaccines.
Inventor(s):	Gale Eugene Smith, Franklin Volvovitz, Bethanie Eident Wilkinson, Craig Stanway Hackett
Assignee:	MG-PMC C/O CONNAUGHT LABORATORIES Inc LLC , SIGMUND A BECK , Protein Sciences Corp
Application Number:	US08/120,607

Details for Patent 5,762,939

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Protein Sciences Corporation	FLUBLOK	influenza vaccine	Injection	125285	January 16, 2013	⤷ Get Started Free	2015-06-09
Protein Sciences Corporation	FLUBLOK	influenza vaccine	Injection	125285	October 07, 2016	⤷ Get Started Free	2015-06-09
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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