Last Updated: April 23, 2026

Claims for Patent: 5,741,894

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Summary for Patent: 5,741,894

Title:	Preparation of pharmaceutical grade hemoglobins by heat treatment in partially oxygenated form
Abstract:	During the purification of pharmaceutical grade crosslinked hemoglobin mixtures of crosslinked and uncrosslinked hemoglobin are heated in the presence of nonstoichiometric amounts of oxygen, resulting in the selective precipitation of the uncrosslinked hemoglobin. After separation of the precipitated uncrosslinked tetramers, the crosslinked hemoglobin remaining in the supernatant is so purified that a further chromatography purification step is unnecessary. This hemoglobin is highly crosslinked absolutely free of chromatography fines, and has a low methemoglobin content.
Inventor(s):	Mahmood Rezazadeh Azari, August A. Ebeling, John E. Picken, Timothy N. Estep
Assignee:	Baxter International Inc
Application Number:	US08/532,293

Details for Patent 5,741,894

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Wyeth Pharmaceuticals Llc	XYNTHA, XYNTHA SOLOFUSE	antihemophilic factor (recombinant), plasma/albumin free	For Injection	125264	February 21, 2008	⤷ Start Trial	2015-09-22
Wyeth Pharmaceuticals Llc	XYNTHA, XYNTHA SOLOFUSE	antihemophilic factor (recombinant), plasma/albumin free	For Injection	125264	August 06, 2010	⤷ Start Trial	2015-09-22
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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