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Last Updated: April 2, 2026

Claims for Patent: 5,733,873

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Summary for Patent: 5,733,873

Title:	Composition comprising coagulation factor VIII formulation, process for its preparation and use of a surfactant as stabilizer
Abstract:	PCT No. PCT/SE93/00793 Sec. 371 Date May 20, 1994 Sec. 102(e) Date May 20, 1994 PCT Filed Oct. 1, 1993 PCT Pub. No. WO94/07510 PCT Pub. Date Apr. 14, 1994A composition comprising coagulation factor VIII and a non-ionic surfactant such as block copolymers, e.g., polyoxamers or polyoxyethylene (20) sorbitan fatty acid esters, e.g., polysorbate 20 or polysorbate 80 as stabilizer is provided. The composition can also comprise sodium chloride, calcium chloride, L-histidine and/or sugars or sugar alcohols.
Inventor(s):	Thomas Osterberg, Angelica Fatouros
Assignee:	Genetics Institute LLC
Application Number:	US08/244,266

Details for Patent 5,733,873

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Takeda Pharmaceuticals U.s.a., Inc.	ADVATE	antihemophilic factor (recombinant), plasma/albumin free method	For Injection	125063	July 25, 2003	⤷ Start Trial	2015-03-31
Takeda Pharmaceuticals U.s.a., Inc.	ADVATE	antihemophilic factor (recombinant), plasma/albumin free method	For Injection	125063	April 12, 2006	⤷ Start Trial	2015-03-31
Takeda Pharmaceuticals U.s.a., Inc.	ADVATE	antihemophilic factor (recombinant), plasma/albumin free method	For Injection	125063	July 03, 2007	⤷ Start Trial	2015-03-31
Takeda Pharmaceuticals U.s.a., Inc.	ADVATE	antihemophilic factor (recombinant), plasma/albumin free method	For Injection	125063	July 12, 2012	⤷ Start Trial	2015-03-31
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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