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Last Updated: April 19, 2024

Claims for Patent: 5,616,491

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Summary for Patent: 5,616,491

Title:	Knockout mice
Abstract:	Mice lacking expression of CD28 or particular CD45 isoforms in certain cells of the immune system are provided. Also provided are methods of using these mice.
Inventor(s):	Mak; Tak W. (Toronto, CA), Thompson; Craig B. (Chicago, IL)
Assignee:	Ontario Cancer Institute (Toronto, CA) Thompson; Craig B. (Chicago, IL)
Application Number:	08/528,363
Patent Claims:	1. A DNA construct comprising intron 1 and exon 2 of a mouse CD28 gene into which a marker sequence has been inserted. 2. The DNA construct of claim 1 wherein said marker sequence comprising a neogene operably linked to a thymidine kinase promoter is substituted for the region between the XbaI site in intron 1 and the EcoRI site in exon 2 of the CD28 gene. 3. A mouse D3 embryonic stem cell line comprising the DNA construct of claim 2 and having the ATCC accession number CRL11382.

Details for Patent 5,616,491

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132	06/04/1986	⤷ Try a Trial	2039-02-26
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132		⤷ Try a Trial	2039-02-26
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	Injection	103132		⤷ Try a Trial	2039-02-26
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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