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Last Updated: September 22, 2020

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Claims for Patent: 5,616,490

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Summary for Patent: 5,616,490
Title: Ribozymes targeted to TNF-.alpha. RNA
Abstract:An enzymatic RNA molecule which cleaves mRNA associated with development or maintenance of an inflammatory disease.
Inventor(s): Sullivan; Sean M. (Boulder, CO), Draper; Kenneth G. (Boulder, CO)
Assignee: Ribozyme Pharmaceuticals, Inc. (Boulder, CO)
Application Number:08/434,503
Patent Claims:1. An enzymatic RNA molecule which specifically cleaves mRNA produced from the gene encoding tumor necrosis factor-.alpha..

2. The enzymatic RNA molecule of claim 1 wherein said enzymatic RNA molecule is in a hammerhead motif.

3. The enzymatic RNA molecule of claim 1, wherein said enzymatic RNA molecule is in a hairpin, hepatitis Delta virus, group 1 intron, or RNAseP RNA motif.

4. The enzymatic RNA molecule of claim 1, wherein said enzymatic RNA molecule comprises between 5 and 23 bases complementary to said mRNA.

5. The enzymatic RNA molecule of claim 1, wherein said enzymatic RNA molecule comprises between 10 and 18 bases complementary to said mRNA.

6. A mammalian cell in vitro including an enzymatic RNA molecule of claim 1.

7. The cell of claim 6, wherein said cell is a human cell.

8. An expression vector including a nucleic acid encoding the enzymatic RNA molecule of claim 1, in a manner which allow expression of that enzymatic RNA molecule within a mammalian cell in vitro.

Details for Patent 5,616,490

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Start Trial Ribozyme Pharmaceuticals, Inc. (Boulder, CO) 2014-04-01 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Start Trial Ribozyme Pharmaceuticals, Inc. (Boulder, CO) 2014-04-01 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Start Trial Ribozyme Pharmaceuticals, Inc. (Boulder, CO) 2014-04-01 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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Serving leading biopharmaceutical companies globally:

Express Scripts
Johnson and Johnson
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Moodys
Boehringer Ingelheim
Colorcon

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