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Last Updated: April 26, 2024

Claims for Patent: 5,616,490

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Summary for Patent: 5,616,490

Title:	Ribozymes targeted to TNF-.alpha. RNA
Abstract:	An enzymatic RNA molecule which cleaves mRNA associated with development or maintenance of an inflammatory disease.
Inventor(s):	Sullivan; Sean M. (Boulder, CO), Draper; Kenneth G. (Boulder, CO)
Assignee:	Ribozyme Pharmaceuticals, Inc. (Boulder, CO)
Application Number:	08/434,503
Patent Claims:	1. An enzymatic RNA molecule which specifically cleaves mRNA produced from the gene encoding tumor necrosis factor-.alpha.. 2. The enzymatic RNA molecule of claim 1 wherein said enzymatic RNA molecule is in a hammerhead motif. 3. The enzymatic RNA molecule of claim 1, wherein said enzymatic RNA molecule is in a hairpin, hepatitis Delta virus, group 1 intron, or RNAseP RNA motif. 4. The enzymatic RNA molecule of claim 1, wherein said enzymatic RNA molecule comprises between 5 and 23 bases complementary to said mRNA. 5. The enzymatic RNA molecule of claim 1, wherein said enzymatic RNA molecule comprises between 10 and 18 bases complementary to said mRNA. 6. A mammalian cell in vitro including an enzymatic RNA molecule of claim 1. 7. The cell of claim 6, wherein said cell is a human cell. 8. An expression vector including a nucleic acid encoding the enzymatic RNA molecule of claim 1, in a manner which allow expression of that enzymatic RNA molecule within a mammalian cell in vitro.

Details for Patent 5,616,490

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132	06/04/1986	⤷ Try a Trial	2014-04-01
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132		⤷ Try a Trial	2014-04-01
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	Injection	103132		⤷ Try a Trial	2014-04-01
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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