You’re using a public version of DrugPatentWatch with 5 free searches available | Register to unlock more free searches. CREATE FREE ACCOUNT

Last Updated: March 29, 2024

Claims for Patent: 5,599,792


✉ Email this page to a colleague

« Back to Dashboard


Summary for Patent: 5,599,792
Title: Bone-stimulating, non-vasoactive parathyroid hormone variants
Abstract:Described herein are Met.sup.8 -substituted variants of parathyroid hormone that retain bone stimulating activity yet, unlike their native counterparts, have substantially no vasoactivity. Their production using recombinant DNA-based techniques is also described, as is their therapeutic use, e.g. in the treatment of osteoporosis.
Inventor(s): Kronis; K. Anne (Toronto, CA), Bozzato; Richard P. (Etobicoke, CA)
Assignee: Allelix Biopharmaceuticals Inc. (Mississauga, CA)
Application Number:08/332,453
Patent Claims:1. A bone-stimulating compound having reduced vasorelaxant activity as compared to natural human parathyroid hormone (hPTH) selected from the group consisting of [Cys.sup.8 ]hPTH (1-84), [Ala.sup.8 ]hPTH (1-84), and [Cys.sup.8 Leu.sup.18 ]hPTH (1-84).

2. A bone-stimulating compound having reduced vasorelaxant activity as compared to natural hPTH as defined in claim 1, wherein said compound is [Cys.sup.8 ]hPTH(1-84).

3. A bone-stimulating compound having reduced vasorelaxant activity as compared to natural hPTH as defined in claim 1, wherein said compound is [Ala.sup.8 ]hPTH(1-84).

4. A bone-stimulating compound having reduced vasorelaxant activity as compared to natural hPTH as defined in claim 1, wherein said compound is [Cys.sup.8 Leu.sup.18 ]hPTH(1-84).

5. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound as claimed in claim 1.

6. A pharmaceutical composition according to claim 5, wherein the compound is [Cys.sup.8 ]hPTH(1-84).

7. A pharmaceutical composition according to claim 5, wherein the compound is [Ala.sup.8 ]hPTH(1-84).

8. A pharmaceutical composition according to claim 5, wherein the compound is [Cys.sup.8 Leu.sup.18 ]hpTH(1-84).

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.