Claims for Patent: 5,407,671

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Summary for Patent: 5,407,671

Title:	One-component tissue adhesive and a process for the production thereof
Abstract:	A description is given of a one-component tissue adhesive containing, in aqueous solution, fibrinogen, F XIII, a thrombin inhibitor, prothrombin factors, calcium ions and, where appropriate, a plasmin inhibitor and of a process for the production thereof. This adhesive can be reconstituted from a freeze-dried form with water. It can contain all active substances in pasteurized form and is then free of the risk of transmission of hepatitis and HTLV III.
Inventor(s):	Heimburger; Norbert (Marburg, DE), Fuhge; Peter (Lahntal, DE), Ronneberger; Hansjorg (Marburg, DE)
Assignee:	Behringwerke Aktiengesellschaft (Marburg/Lahn, DE)
Application Number:	07/983,613
Patent Claims:	1. A one component tissue adhesive in solid form having as active substances when reconstituted in 1 ml of solution: 65-115 mg of human fibrinogen, 40-80 U of factor XIII, 1-50 IU of PPSB (prothrombin factors) based on factor II (prothrombin), 0.01-50 IU of antithrombin III, 0.1-5 mmol/l of calcium ions, and 1-10,000 KIU of aprotinin, wherein the ratio of said active substances is such that there is no premature coagulation of said adhesive during preparation, and such that coagulation is initiated on contact with a wound surface.

Details for Patent 5,407,671

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Bayer Healthcare Pharmaceuticals Inc.	TRASYLOL	aprotinin	Injection	020304	December 29, 1993	⤷ Get Started Free	2012-11-30
Csl Behring Gmbh	RIASTAP	fibrinogen concentrate (human)	For Injection	125317	January 16, 2009	⤷ Get Started Free	2012-11-30
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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