Claims for Patent: 5,401,650

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Summary for Patent: 5,401,650

Title:	Cloning and expression of biologically active α-galactosidase A
Abstract:	The present invention involves the production of large quantities of human alpha -Gal A by cloning and expressing the alpha -Gal A coding sequence in eukaryotic host cell expression systems. The eukaryotic expression systems, and in particular the mammalian host cell expression system described herein provide for the appropriate cotranslational and posttranslational modifications required for proper processing, e.g., glycosylation, phosphorylation, etc. and sorting of the expression product so that an active enzyme is produced. In addition, the expression of fusion proteins which simplify purification is described. Using the methods described herein, the recombinant alpha -Gal A is secreted by the engineered host cells so that it is recovered from the culture medium in good yield. The alpha -Gal A produced in accordance with the invention may be used, but is not limited to, in the treatment in Fabry Disease; for the hydrolysis of alpha -galactosyl residues in glycoconjugates; and/or for the conversion of the blood group B antigen on erythrocytes to the blood group O antigen.
Inventor(s):	Robert J. Desnick, David F. Bishop, Yiannis A. Ioannou
Assignee:	Icahn School of Medicine at Mount Sinai
Application Number:	US07/983,451

Details for Patent 5,401,650

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Genzyme Corporation	FABRAZYME	agalsidase beta	For Injection	103979	April 24, 2003	5,401,650	2012-11-30
Genzyme Corporation	FABRAZYME	agalsidase beta	For Injection	103979	October 10, 2003	5,401,650	2012-11-30
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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