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Last Updated: March 29, 2024

Claims for Patent: 5,393,792


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Summary for Patent: 5,393,792
Title: High dosage topical forms of collagenase
Abstract:High concentrations of collagenase as active ingredient in non-aqueous topical pharmaceutical formulations.
Inventor(s): Stern; Harold (Baldwin Harbor, NY), Yee; David (Oceanside, NY)
Assignee: Advance Biofactures of Curacao, N.V. (Brievengat, AN)
Application Number:07/963,995
Patent Claims:1. A pharmaceutical composition for topical use consisting essentially of an intimate physical admixture of a non-aqueous excipient and at least about 1,500 ABC units of collagenase per gram of excipient.

2. A composition according to claim 1 in the form of an ointment.

3. A composition according to claim 2 wherein the excipient is petrolatum.

4. A composition according to claim 2 containing from about 1,500 to about 5,000 ABC units of collagenase per gram of excipient.

5. A composition according to claim 1 wherein the excipient is a dry powder.

6. A composition according to claim 5 wherein the excipient is lactose.

7. A composition according to claim 5 wherein the excipient is a mixture of polymixin B sulfate and bacitracin in powder form.

8. A composition according to claim 5 containing from about 2,500 to about 10,000 ABC units of collagenase per gram of excipient.

9. A pharmaceutical composition for topical use consisting essentially of a dry powdered intimate physical admixture of dextran as excipient and in excess of 5,000 ABC units collagenase per gram of dextran.

10. A composition according to claim 5 containing at least about 8,000 ABC units of collagenase per gram of excipient.

11. A composition according to claim 1 that also contains an antibiotic or antiseptic.

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