Claims for Patent: 5,382,524

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Summary for Patent: 5,382,524

Title:	Cloning and expression of biologically active α-n-acetylgalactosaminidase
Abstract:	The present invention involves the production of human alpha -GalNAc by cloning and expressing the alpha -GalNAc coding sequence in eukaryotic host cell expressions systems. The eukaryotic expression systems, and in particular the mammalian host cell expression systems described herein provide for the appropriate co-translational and post-translation modifications required or proper processing, e.g., glycosylation, phosphorylation, etc. and sorting of the expression product so that an active enzyme is produced. The alpha -GalNAc produced in accordance with the invention may be used in the treatment of Schindler disease or for the hydrolysis of alpha -N-acetylgalactosaminyl moieties in various glycoconjugates.
Inventor(s):	Robert J. Desnick, David F. Bishop, Yiannis A. Ioannou, Anne M. Wang
Assignee:	Icahn School of Medicine at Mount Sinai
Application Number:	US07/602,608

Details for Patent 5,382,524

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Genzyme Corporation	FABRAZYME	agalsidase beta	For Injection	103979	April 24, 2003	5,382,524	2012-01-17
Genzyme Corporation	FABRAZYME	agalsidase beta	For Injection	103979	October 10, 2003	5,382,524	2012-01-17
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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