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Last Updated: May 21, 2024

Claims for Patent: 5,372,808

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Summary for Patent: 5,372,808

Title:	Methods and compositions for the treatment of diseases with consensus interferon while reducing side effect
Abstract:	Methods for the treatment of cell proliferation disorders, viral infections, and other conditions without causing significant side effects normally associated with interferon therapy, involving administering to a patient in need thereof a therapeutically effective amount of consensus human leukocyte interferon are disclosed. Also disclosed are pharmaceutical compositions of consensus human leukocyte interferon.
Inventor(s):	Blatt; Lawrence M. (Ventura, CA), Taylor; Milton W. (Bloomington, IN)
Assignee:	Amgen Inc. (Thousand Oaks, CA)
Application Number:	07/868,916
Patent Claims:	1. A method for treating a patient having a viral disease selected from the group consisting of hepatitis A, hepatitis B, hepatitis C or hepatitis Delta while reducing the occurrence of Grade 3or 4 toxicities associated with alpha interferon treatment as measured by the World Health Organization toxicity scale, which comprises administering to said patient a therapeutically effective amount of a consensus human leukocyte interferon. 2. A method according to claim 1, wherein said viral disease is hepatitis A. 3. A method according to claim 1, wherein said viral disease is hepatitis B. 4. A method according to claim 1, wherein said viral disease is hepatitis C. 5. A method according to claim 1, wherein said viral disease is hepatitis Delta. 6. A method for treating a patient having Kaposi's Sarcoma while reducing the occurrence of Grade 3 or 4 toxicities associated with alpha interferon treatment as measured by the World Health Organization toxicity scale, which comprises administering to said patient a therapeutically effective amount of a consensus human leukocyte interferon. 7. A method according to claim 1 or 6, wherein said toxicities are selected from the group consisting of headache, fever, chills, nausea, anorexia. depression, and insomnia. 8. A method according to claim 1 or 6, wherein the consensus human leukocyte interferon is :;elected from the group consisting of IFN-con.sub.1, IFN-con.sub.2, and IFN-con.sub.3. 9. A method according to claim 1 or 6, wherein the consensus human leukocyte interretort is ZFN-con.sub.1. 10. A method according to claim 1 or 6, wherein the consensus human leukocyte interferon is a product of procaryotic expression of an exogenous DNA sequence. 11. A method according to claim 1 or 6, wherein the therapeutically effective amount is administered by a route of administration selected from the group consisting of oral, intravenous, intramuscular. subcutaneous, intranasal, and intralesional. 12. A method according; to claim 1 or 6, wherein the therapeutically effective amount of consensus human leukocyte interferon is from 2.times.10.sup.6 to 30.times.10.sup.6 units per patient. 13. A method according to claim 1 or 6, wherein the therapeutically effective amount of consensus human leukocyte interferon is from 6.times.10.sup.6 to 15.times.10.sup.6 units per patient. 14. A method according to claim 1 or 6, wherein the patient is a human. 15. A method according to claim 1 or 6, further comprising administering a therapeutically effective amount of a chemotherapeutic agent. 16. A method according to claim 1 or 6, further comprising administering: a therapeutically effective amount of G-CSF.

Details for Patent 5,372,808

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Kadmon Pharmaceuticals Llc	INFERGEN	interferon alfacon-1	Injection	103663	10/06/1997	⤷ Sign Up	2011-12-13
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 5,372,808

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Country	Patent Number	Estimated Expiration
South Africa	932641	⤷ Sign Up
World Intellectual Property Organization (WIPO)	9321229	⤷ Sign Up
World Intellectual Property Organization (WIPO)	9206707	⤷ Sign Up
>Country	>Patent Number	>Estimated Expiration

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